The 68Ga and 111In complexes of PLED (N,N'-dipyridoxylethylenediamine-N,N'-diacetic acid) were prepared and their biodistribution determined as a function of time following i.v. injection into rats. The 68Ga and 111In complexes behaved identically and were rapidly cleared from the blood via the kidneys into the urine. Similar rapid urinary excretion was observed in the gamma images obtained from a stump-tailed macaque injected with 111In-PLED. Paper electrophoresis at pH 7.35 showed a single radioactive peak for 111In-PLED which migrated towards the anode. PLED administered by i.p. injection was found to speed the blood pool clearance of previously administered 68Ga-citrate.
|Original language||English (US)|
|Number of pages||6|
|Journal||International Journal of Nuclear Medicine and Biology|
|State||Published - Jan 1 1985|
ASJC Scopus subject areas
- Radiology Nuclear Medicine and imaging