Evaluation of PLED as a chelating ligand for the preparation of gallium and indium radiopharmaceuticals

Mark A. Green, Michael J. Welch, Carla J. Mathias, Patrick Taylor, Arthur E. Martell

Research output: Contribution to journalArticle

17 Scopus citations

Abstract

The 68Ga and 111In complexes of PLED (N,N'-dipyridoxylethylenediamine-N,N'-diacetic acid) were prepared and their biodistribution determined as a function of time following i.v. injection into rats. The 68Ga and 111In complexes behaved identically and were rapidly cleared from the blood via the kidneys into the urine. Similar rapid urinary excretion was observed in the gamma images obtained from a stump-tailed macaque injected with 111In-PLED. Paper electrophoresis at pH 7.35 showed a single radioactive peak for 111In-PLED which migrated towards the anode. PLED administered by i.p. injection was found to speed the blood pool clearance of previously administered 68Ga-citrate.

Original languageEnglish (US)
Pages (from-to)381-386
Number of pages6
JournalInternational Journal of Nuclear Medicine and Biology
Volume12
Issue number5
DOIs
StatePublished - Jan 1 1985
Externally publishedYes

ASJC Scopus subject areas

  • Radiology Nuclear Medicine and imaging

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