Retinale hamodynamik bei patienten mit normaldruckglaukom: Quantifizierung mittels digitaler scanning-laser-fluoreszein-angiographie

Translated title of the contribution: Evaluation of retinal hemodynamics by means of digital scanning laser fluorescence angiography in normal-tension glaucoma

Oliver Arend, Andreas Remky, Claudia Redbrake, Susanne Arend, Martin Wenzel, A. Harris

Research output: Contribution to journalArticle

22 Citations (Scopus)

Abstract

Chronic ischemia of the retina and the optic nerve head seems of importance especially in patients with normal-tension glaucoma (NTG). The purpose of this study was to examine the retinal hemodynamics in patients with NTG. Patients: Twenty-five patients with NTG were examined (3 weeks washout period) in this study (age 58 ± 16 years). The arteriovenous passage (AVP) time and arterial and venous diameters from scanning laser fluorescein angiograms were evaluated by means of digital image analysis. Results: The AVP time in patients with NTG (2.78 ± 1.1 s) was significantly prolonged (P < 0.0001) compared with healthy subjects (1.58 ± 0.4 s). No significant correlation was found between arterial and venous diameters, intraocular pressure, blood pressure or calculated perfusion pressure and retinal arteriovenous passage time. Conclusion: Patients with NTG showed prolonged retinal passage, which could cause chronic hypoxia. This prolongation of circulation is not correlated with any of the clinical parameters. Thus, a circulatory defect might be a primary factor in the pathogenesis of NTG.

Original languageGerman
Pages (from-to)24-29
Number of pages6
JournalOphthalmologe
Volume96
Issue number1
DOIs
StatePublished - Jan 1999

Fingerprint

Low Tension Glaucoma
Fluorescein Angiography
Lasers
Hemodynamics
Optic Disk
Fluorescein
Intraocular Pressure
Retina
Healthy Volunteers
Angiography
Ischemia
Perfusion
Blood Pressure
Pressure

Keywords

  • Fluorescein angiography
  • Normal-tension glaucoma
  • Optic nerve head cupping

ASJC Scopus subject areas

  • Ophthalmology

Cite this

Retinale hamodynamik bei patienten mit normaldruckglaukom : Quantifizierung mittels digitaler scanning-laser-fluoreszein-angiographie. / Arend, Oliver; Remky, Andreas; Redbrake, Claudia; Arend, Susanne; Wenzel, Martin; Harris, A.

In: Ophthalmologe, Vol. 96, No. 1, 01.1999, p. 24-29.

Research output: Contribution to journalArticle

Arend, Oliver ; Remky, Andreas ; Redbrake, Claudia ; Arend, Susanne ; Wenzel, Martin ; Harris, A. / Retinale hamodynamik bei patienten mit normaldruckglaukom : Quantifizierung mittels digitaler scanning-laser-fluoreszein-angiographie. In: Ophthalmologe. 1999 ; Vol. 96, No. 1. pp. 24-29.
@article{2502afd1a8f442ed968c3b2299d0117c,
title = "Retinale hamodynamik bei patienten mit normaldruckglaukom: Quantifizierung mittels digitaler scanning-laser-fluoreszein-angiographie",
abstract = "Chronic ischemia of the retina and the optic nerve head seems of importance especially in patients with normal-tension glaucoma (NTG). The purpose of this study was to examine the retinal hemodynamics in patients with NTG. Patients: Twenty-five patients with NTG were examined (3 weeks washout period) in this study (age 58 ± 16 years). The arteriovenous passage (AVP) time and arterial and venous diameters from scanning laser fluorescein angiograms were evaluated by means of digital image analysis. Results: The AVP time in patients with NTG (2.78 ± 1.1 s) was significantly prolonged (P < 0.0001) compared with healthy subjects (1.58 ± 0.4 s). No significant correlation was found between arterial and venous diameters, intraocular pressure, blood pressure or calculated perfusion pressure and retinal arteriovenous passage time. Conclusion: Patients with NTG showed prolonged retinal passage, which could cause chronic hypoxia. This prolongation of circulation is not correlated with any of the clinical parameters. Thus, a circulatory defect might be a primary factor in the pathogenesis of NTG.",
keywords = "Fluorescein angiography, Normal-tension glaucoma, Optic nerve head cupping",
author = "Oliver Arend and Andreas Remky and Claudia Redbrake and Susanne Arend and Martin Wenzel and A. Harris",
year = "1999",
month = "1",
doi = "10.1007/s003470050371",
language = "German",
volume = "96",
pages = "24--29",
journal = "Der Ophthalmologe",
issn = "0941-293X",
publisher = "Springer Verlag",
number = "1",

}

TY - JOUR

T1 - Retinale hamodynamik bei patienten mit normaldruckglaukom

T2 - Quantifizierung mittels digitaler scanning-laser-fluoreszein-angiographie

AU - Arend, Oliver

AU - Remky, Andreas

AU - Redbrake, Claudia

AU - Arend, Susanne

AU - Wenzel, Martin

AU - Harris, A.

PY - 1999/1

Y1 - 1999/1

N2 - Chronic ischemia of the retina and the optic nerve head seems of importance especially in patients with normal-tension glaucoma (NTG). The purpose of this study was to examine the retinal hemodynamics in patients with NTG. Patients: Twenty-five patients with NTG were examined (3 weeks washout period) in this study (age 58 ± 16 years). The arteriovenous passage (AVP) time and arterial and venous diameters from scanning laser fluorescein angiograms were evaluated by means of digital image analysis. Results: The AVP time in patients with NTG (2.78 ± 1.1 s) was significantly prolonged (P < 0.0001) compared with healthy subjects (1.58 ± 0.4 s). No significant correlation was found between arterial and venous diameters, intraocular pressure, blood pressure or calculated perfusion pressure and retinal arteriovenous passage time. Conclusion: Patients with NTG showed prolonged retinal passage, which could cause chronic hypoxia. This prolongation of circulation is not correlated with any of the clinical parameters. Thus, a circulatory defect might be a primary factor in the pathogenesis of NTG.

AB - Chronic ischemia of the retina and the optic nerve head seems of importance especially in patients with normal-tension glaucoma (NTG). The purpose of this study was to examine the retinal hemodynamics in patients with NTG. Patients: Twenty-five patients with NTG were examined (3 weeks washout period) in this study (age 58 ± 16 years). The arteriovenous passage (AVP) time and arterial and venous diameters from scanning laser fluorescein angiograms were evaluated by means of digital image analysis. Results: The AVP time in patients with NTG (2.78 ± 1.1 s) was significantly prolonged (P < 0.0001) compared with healthy subjects (1.58 ± 0.4 s). No significant correlation was found between arterial and venous diameters, intraocular pressure, blood pressure or calculated perfusion pressure and retinal arteriovenous passage time. Conclusion: Patients with NTG showed prolonged retinal passage, which could cause chronic hypoxia. This prolongation of circulation is not correlated with any of the clinical parameters. Thus, a circulatory defect might be a primary factor in the pathogenesis of NTG.

KW - Fluorescein angiography

KW - Normal-tension glaucoma

KW - Optic nerve head cupping

UR - http://www.scopus.com/inward/record.url?scp=0032587180&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=0032587180&partnerID=8YFLogxK

U2 - 10.1007/s003470050371

DO - 10.1007/s003470050371

M3 - Article

C2 - 10067331

AN - SCOPUS:0032587180

VL - 96

SP - 24

EP - 29

JO - Der Ophthalmologe

JF - Der Ophthalmologe

SN - 0941-293X

IS - 1

ER -