Evaluation of the treatment of Stenotrophomonas maltophilia in tracheostomy-dependent pediatric patients

Emma M. Tillman, Sarah E. Firmani, Veda L. Ackerman, James E. Slaven, A. Ioana Cristea

Research output: Contribution to journalArticle


OBJECTIVE Tracheostomy-dependent pediatric patients will often have respiratory cultures positive for Stenotrophomonas maltophilia (multidrug-resistant Gram-negative rod). There are limited data available to guide treatment in this population. The objective of this single-center, retrospective study was to evaluate if antibiotic treatment of S maltophilia improved clinical outcomes in tracheostomy-dependent pediatric patients. METHODS We included tracheostomy-dependent pediatric patients who had a respiratory culture positive for S maltophilia. Patients were divided into 2 groups: 1) treatment and 2) no treatment. RESULTS Forty patients with 55 encounters were included in this study. S maltophilia was treated with sulfamethoxazole-trimethoprim in 20 encounters (19 patients) and no antimicrobial treatment was given in 35 encounters (30 patients). The time to return to stable respiratory status was 5 days (0–10) (median [range]) in the treated group and 4 days (0–19) in the untreated group (p = 0.52). There was no statistically significant difference in time to baseline respiratory status between patients treated and those not treated for S maltophilia. There was no difference in hospital length of stay between patients who were or not treated. CONCLUSIONS Based on these results, these data would suggest that there might not be a benefit to treating cultures positive for S maltophilia in tracheostomy-dependent pediatric patients.

Original languageEnglish (US)
Pages (from-to)510-517
Number of pages8
JournalJournal of Pediatric Pharmacology and Therapeutics
Issue number6
StatePublished - Nov 1 2019


  • Child
  • Gram-negative bacterial infections
  • Lung diseases
  • Stenotrophomonas maltophilia
  • Tracheostomy

ASJC Scopus subject areas

  • Pediatrics, Perinatology, and Child Health
  • Pharmacology (medical)

Fingerprint Dive into the research topics of 'Evaluation of the treatment of Stenotrophomonas maltophilia in tracheostomy-dependent pediatric patients'. Together they form a unique fingerprint.

  • Cite this