Evidence for a locus on chromosome 1 that influences vulnerability to alcoholism and affective disorder

John I. Nurnberger, Tatiana Foroud, Leah Flury, Jessica Su, Eric T. Meyer, Kuolung Hu, Raymond Crowe, Howard Edenberg, Alison Goate, Laura Bierut, Theodore Reich, Marc Schuckit, Wendy Reich

Research output: Contribution to journalArticle

164 Citations (Scopus)

Abstract

Objective: Depression (major depression or depressive syndrome) is more prevalent in alcoholic than in nonalcoholic subjects in families with multiple members with alcoholism studied as part of the Collaborative Study on the Genetics of Alcoholism (National Institute on Alcohol Abuse and Alcoholism). First-degree relatives of probands with comorbid alcoholism and depression have a higher prevalence of both disorders than relatives of probands with alcoholism alone, and both groups have a higher prevalence than the relatives of comparison subjects selected without regard to psychopathology. Data from the collaborative study were used to test three phenotypes (comorbid alcoholism and depression, alcoholism or depression, and depression) for genetic lin kage. Method: Genome-wide sibling-pair linkage analyses were performed with the phenotypes comorbid alcoholism and depression, alcoholism or depression, and depression (major depression or depressive syndrome). Analyses were performed in two data sets (initial and replication data sets) from subject groups ascertained with identical criteria, as well as in the combined data set. Results: Peak lod scores on chromosome 1 (near 120 centimorgan) for the alcoholism or depression phenotype were 5.12, 1.52, and 4.66 in the initial, replication, and combined data sets, respectively. The corresponding lod scores on chromosome 2 were 2.79, 0.20, and 3.26; on chromosome 6, they were 3.39, 0.00, and 0.92; and on chromosome 16, they were 3.13, 0.00, and 2.06. Lod scores on chromosome 2 for the comorbid alcoholism and depression phenotype in the three data sets were 0.00, 4.12, and 2.16, respectively. Conclusions: The results suggest that a gene or genes on chromosome 1 may predispose some individuais to alcoholism and others to depression (which may be alcohol induced). Loci on other chromosomes may also be of interest.

Original languageEnglish (US)
Pages (from-to)718-724
Number of pages7
JournalAmerican Journal of Psychiatry
Volume158
Issue number5
DOIs
StatePublished - May 1 2001

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Chromosomes, Human, Pair 1
Mood Disorders
Alcoholism
Depression
Lod Score
Phenotype
Chromosomes, Human, Pair 2
Depressive Disorder
National Institute on Alcohol Abuse and Alcoholism (U.S.)
Chromosomes, Human, Pair 16
Chromosomes, Human, Pair 6
Psychopathology
Genes
Chromosomes

ASJC Scopus subject areas

  • Psychiatry and Mental health

Cite this

Evidence for a locus on chromosome 1 that influences vulnerability to alcoholism and affective disorder. / Nurnberger, John I.; Foroud, Tatiana; Flury, Leah; Su, Jessica; Meyer, Eric T.; Hu, Kuolung; Crowe, Raymond; Edenberg, Howard; Goate, Alison; Bierut, Laura; Reich, Theodore; Schuckit, Marc; Reich, Wendy.

In: American Journal of Psychiatry, Vol. 158, No. 5, 01.05.2001, p. 718-724.

Research output: Contribution to journalArticle

Nurnberger, JI, Foroud, T, Flury, L, Su, J, Meyer, ET, Hu, K, Crowe, R, Edenberg, H, Goate, A, Bierut, L, Reich, T, Schuckit, M & Reich, W 2001, 'Evidence for a locus on chromosome 1 that influences vulnerability to alcoholism and affective disorder', American Journal of Psychiatry, vol. 158, no. 5, pp. 718-724. https://doi.org/10.1176/appi.ajp.158.5.718
Nurnberger, John I. ; Foroud, Tatiana ; Flury, Leah ; Su, Jessica ; Meyer, Eric T. ; Hu, Kuolung ; Crowe, Raymond ; Edenberg, Howard ; Goate, Alison ; Bierut, Laura ; Reich, Theodore ; Schuckit, Marc ; Reich, Wendy. / Evidence for a locus on chromosome 1 that influences vulnerability to alcoholism and affective disorder. In: American Journal of Psychiatry. 2001 ; Vol. 158, No. 5. pp. 718-724.
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abstract = "Objective: Depression (major depression or depressive syndrome) is more prevalent in alcoholic than in nonalcoholic subjects in families with multiple members with alcoholism studied as part of the Collaborative Study on the Genetics of Alcoholism (National Institute on Alcohol Abuse and Alcoholism). First-degree relatives of probands with comorbid alcoholism and depression have a higher prevalence of both disorders than relatives of probands with alcoholism alone, and both groups have a higher prevalence than the relatives of comparison subjects selected without regard to psychopathology. Data from the collaborative study were used to test three phenotypes (comorbid alcoholism and depression, alcoholism or depression, and depression) for genetic lin kage. Method: Genome-wide sibling-pair linkage analyses were performed with the phenotypes comorbid alcoholism and depression, alcoholism or depression, and depression (major depression or depressive syndrome). Analyses were performed in two data sets (initial and replication data sets) from subject groups ascertained with identical criteria, as well as in the combined data set. Results: Peak lod scores on chromosome 1 (near 120 centimorgan) for the alcoholism or depression phenotype were 5.12, 1.52, and 4.66 in the initial, replication, and combined data sets, respectively. The corresponding lod scores on chromosome 2 were 2.79, 0.20, and 3.26; on chromosome 6, they were 3.39, 0.00, and 0.92; and on chromosome 16, they were 3.13, 0.00, and 2.06. Lod scores on chromosome 2 for the comorbid alcoholism and depression phenotype in the three data sets were 0.00, 4.12, and 2.16, respectively. Conclusions: The results suggest that a gene or genes on chromosome 1 may predispose some individuais to alcoholism and others to depression (which may be alcohol induced). Loci on other chromosomes may also be of interest.",
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T1 - Evidence for a locus on chromosome 1 that influences vulnerability to alcoholism and affective disorder

AU - Nurnberger, John I.

AU - Foroud, Tatiana

AU - Flury, Leah

AU - Su, Jessica

AU - Meyer, Eric T.

AU - Hu, Kuolung

AU - Crowe, Raymond

AU - Edenberg, Howard

AU - Goate, Alison

AU - Bierut, Laura

AU - Reich, Theodore

AU - Schuckit, Marc

AU - Reich, Wendy

PY - 2001/5/1

Y1 - 2001/5/1

N2 - Objective: Depression (major depression or depressive syndrome) is more prevalent in alcoholic than in nonalcoholic subjects in families with multiple members with alcoholism studied as part of the Collaborative Study on the Genetics of Alcoholism (National Institute on Alcohol Abuse and Alcoholism). First-degree relatives of probands with comorbid alcoholism and depression have a higher prevalence of both disorders than relatives of probands with alcoholism alone, and both groups have a higher prevalence than the relatives of comparison subjects selected without regard to psychopathology. Data from the collaborative study were used to test three phenotypes (comorbid alcoholism and depression, alcoholism or depression, and depression) for genetic lin kage. Method: Genome-wide sibling-pair linkage analyses were performed with the phenotypes comorbid alcoholism and depression, alcoholism or depression, and depression (major depression or depressive syndrome). Analyses were performed in two data sets (initial and replication data sets) from subject groups ascertained with identical criteria, as well as in the combined data set. Results: Peak lod scores on chromosome 1 (near 120 centimorgan) for the alcoholism or depression phenotype were 5.12, 1.52, and 4.66 in the initial, replication, and combined data sets, respectively. The corresponding lod scores on chromosome 2 were 2.79, 0.20, and 3.26; on chromosome 6, they were 3.39, 0.00, and 0.92; and on chromosome 16, they were 3.13, 0.00, and 2.06. Lod scores on chromosome 2 for the comorbid alcoholism and depression phenotype in the three data sets were 0.00, 4.12, and 2.16, respectively. Conclusions: The results suggest that a gene or genes on chromosome 1 may predispose some individuais to alcoholism and others to depression (which may be alcohol induced). Loci on other chromosomes may also be of interest.

AB - Objective: Depression (major depression or depressive syndrome) is more prevalent in alcoholic than in nonalcoholic subjects in families with multiple members with alcoholism studied as part of the Collaborative Study on the Genetics of Alcoholism (National Institute on Alcohol Abuse and Alcoholism). First-degree relatives of probands with comorbid alcoholism and depression have a higher prevalence of both disorders than relatives of probands with alcoholism alone, and both groups have a higher prevalence than the relatives of comparison subjects selected without regard to psychopathology. Data from the collaborative study were used to test three phenotypes (comorbid alcoholism and depression, alcoholism or depression, and depression) for genetic lin kage. Method: Genome-wide sibling-pair linkage analyses were performed with the phenotypes comorbid alcoholism and depression, alcoholism or depression, and depression (major depression or depressive syndrome). Analyses were performed in two data sets (initial and replication data sets) from subject groups ascertained with identical criteria, as well as in the combined data set. Results: Peak lod scores on chromosome 1 (near 120 centimorgan) for the alcoholism or depression phenotype were 5.12, 1.52, and 4.66 in the initial, replication, and combined data sets, respectively. The corresponding lod scores on chromosome 2 were 2.79, 0.20, and 3.26; on chromosome 6, they were 3.39, 0.00, and 0.92; and on chromosome 16, they were 3.13, 0.00, and 2.06. Lod scores on chromosome 2 for the comorbid alcoholism and depression phenotype in the three data sets were 0.00, 4.12, and 2.16, respectively. Conclusions: The results suggest that a gene or genes on chromosome 1 may predispose some individuais to alcoholism and others to depression (which may be alcohol induced). Loci on other chromosomes may also be of interest.

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