Evidence for an N-glycosylation polymorphism of arylsulfatase a predisposing to alcoholism in Koreans

In Won Chungheon Kim, Sang Ick Lee, Joo Bong Hong, Yong Dae Kim, Hongmei Nan, William Sribney, Yong Sik Kim, Paul Manowitz

Research output: Contribution to journalArticle

3 Citations (Scopus)

Abstract

This study investigated the possible effect of the pseudodeficient N-glycosylation polymorphism of the arylsulfatase A (ASA) gene on alcohol dependence among Koreans. Alcoholic patients (N=123) were more likely than control subjects to be heterozygous or homozygous for the ASA pseudodeficient N-glycosylation site (36% of alcoholics versus 20% of controls; P < 0.01). Among these 123 alcoholic patients, 42 alcoholics were heterozygous and two were homozygous for the ASA pseudodeficient N-glycosylation polymorphism. This result provides evidence that the ASA pseudodeficient N-glycosylation site allele increases the risk of alcohol dependence within a Korean population.

Original languageEnglish (US)
Pages (from-to)186-189
Number of pages4
JournalAmerican Journal of Medical Genetics - Neuropsychiatric Genetics
Volume114
Issue number2
DOIs
StatePublished - Mar 8 2002
Externally publishedYes

Fingerprint

Cerebroside-Sulfatase
Arylsulfatases
Alcoholics
Glycosylation
Alcoholism
Alleles
Population
Genes

Keywords

  • Alcoholism
  • Aldehyde dehydrogenase II (ALDH2)
  • Arylsulfatase A (ASA)
  • Polymorphisms

ASJC Scopus subject areas

  • Genetics(clinical)
  • Psychiatry and Mental health
  • Cellular and Molecular Neuroscience

Cite this

Evidence for an N-glycosylation polymorphism of arylsulfatase a predisposing to alcoholism in Koreans. / Kim, In Won Chungheon; Lee, Sang Ick; Hong, Joo Bong; Kim, Yong Dae; Nan, Hongmei; Sribney, William; Kim, Yong Sik; Manowitz, Paul.

In: American Journal of Medical Genetics - Neuropsychiatric Genetics, Vol. 114, No. 2, 08.03.2002, p. 186-189.

Research output: Contribution to journalArticle

Kim, In Won Chungheon ; Lee, Sang Ick ; Hong, Joo Bong ; Kim, Yong Dae ; Nan, Hongmei ; Sribney, William ; Kim, Yong Sik ; Manowitz, Paul. / Evidence for an N-glycosylation polymorphism of arylsulfatase a predisposing to alcoholism in Koreans. In: American Journal of Medical Genetics - Neuropsychiatric Genetics. 2002 ; Vol. 114, No. 2. pp. 186-189.
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