Evidence for an N-glycosylation polymorphism of arylsulfatase a predisposing to alcoholism in Koreans

In Won Chungheon Kim, Sang Ick Lee, Joo Bong Hong, Yong Dae Kim, Hong Mei Nan, William Sribney, Yong Sik Kim, Paul Manowitz

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This study investigated the possible effect of the pseudodeficient N-glycosylation polymorphism of the arylsulfatase A (ASA) gene on alcohol dependence among Koreans. Alcoholic patients (N=123) were more likely than control subjects to be heterozygous or homozygous for the ASA pseudodeficient N-glycosylation site (36% of alcoholics versus 20% of controls; P < 0.01). Among these 123 alcoholic patients, 42 alcoholics were heterozygous and two were homozygous for the ASA pseudodeficient N-glycosylation polymorphism. This result provides evidence that the ASA pseudodeficient N-glycosylation site allele increases the risk of alcohol dependence within a Korean population.

Original languageEnglish (US)
Pages (from-to)186-189
Number of pages4
JournalAmerican Journal of Medical Genetics - Neuropsychiatric Genetics
Issue number2
StatePublished - Mar 8 2002



  • Alcoholism
  • Aldehyde dehydrogenase II (ALDH2)
  • Arylsulfatase A (ASA)
  • Polymorphisms

ASJC Scopus subject areas

  • Genetics(clinical)
  • Psychiatry and Mental health
  • Cellular and Molecular Neuroscience

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