Evidence for BCR/ABL1-positive T-cell acute lymphoblastic leukemia arising in an early lymphoid progenitor cell

Susanne Ragg, Barbara K. Zehentner, Michael R. Loken, James Croop

Research output: Contribution to journalArticle

Abstract

BCR-ABL1-positive leukemias have historically been classified as either chronic myelogenous leukemia or Ph+ acute lymphoblastic leukemia. Recent analyses suggest there may be a wider range of subtypes. We report a patient with BCR-ABL1 fusion positive T-cell ALL with a previously undescribed cell distribution of the fusion gene. The examination of sorted cells by fluorescence in situ hybridization showed the BCR-ABL1 fusion in the malignant T cells and a subpopulation of the nonmalignant B cells, but not nonmalignant T cells or myeloid or CD34+ progenitor cells providing evidence that the fusion may have occurred in an early lymphoid progenitor.

Original languageEnglish (US)
Article numbere27829
JournalPediatric Blood and Cancer
Volume66
Issue number9
DOIs
StatePublished - Sep 1 2019

Fingerprint

Lymphoid Progenitor Cells
Precursor T-Cell Lymphoblastic Leukemia-Lymphoma
T-Lymphocytes
Cell Fusion
Leukemia, Myelogenous, Chronic, BCR-ABL Positive
Fluorescence In Situ Hybridization
Precursor Cell Lymphoblastic Leukemia-Lymphoma
Leukemia
B-Lymphocytes
Stem Cells
Genes

Keywords

  • BCR-ABL1
  • discordant MRD
  • T-cell ALL

ASJC Scopus subject areas

  • Pediatrics, Perinatology, and Child Health
  • Hematology
  • Oncology

Cite this

Evidence for BCR/ABL1-positive T-cell acute lymphoblastic leukemia arising in an early lymphoid progenitor cell. / Ragg, Susanne; Zehentner, Barbara K.; Loken, Michael R.; Croop, James.

In: Pediatric Blood and Cancer, Vol. 66, No. 9, e27829, 01.09.2019.

Research output: Contribution to journalArticle

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