Evidence for the transformation of seminoma to yolk sac tumor, with histogenetic considerations

J. T. Czaja, Thomas Ulbright

Research output: Contribution to journalArticle

33 Citations (Scopus)

Abstract

Recent ultrastructural, cytogenetic, and ploidy analyses indicate that seminoma acts as a precursor from which other forms of testicular germ cell tumor may originate. Ten cases of primary or metastatic testicular germ cell tumors were investigated that showed possible transformation of seminoma to yolk sac tumor. Such transformation was identified in six cases in which foci of abrupt change from seminoma to various patterns of yolk sac tumor occurred, often at the periphery of otherwise pure lobules of seminoma. Immunostains for cytokeratins, placental-like alkaline phosphatase, and alpha-fetoprotein demonstrated the expected changes in reactivity at the foci of such transformation. Four additional cases were regarded as either seminomas with artifactual microcystic change or the close association of seminoma and yolk sac tumor but lacking evidence for transformation. These data support the theory that seminoma is not an 'endpoint' neoplasm but may serve a precursor role in the progression to nonseminomatous germ cell tumors.

Original languageEnglish
Pages (from-to)468-477
Number of pages10
JournalAmerican Journal of Clinical Pathology
Volume97
Issue number4
StatePublished - 1992

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Endodermal Sinus Tumor
Seminoma
Ploidies
Cytogenetic Analysis
alpha-Fetoproteins
Keratins

Keywords

  • Germ cell tumor
  • Histogenesis
  • Seminoma
  • Testicular neoplasm
  • Yolk sac tumor

ASJC Scopus subject areas

  • Pathology and Forensic Medicine

Cite this

Evidence for the transformation of seminoma to yolk sac tumor, with histogenetic considerations. / Czaja, J. T.; Ulbright, Thomas.

In: American Journal of Clinical Pathology, Vol. 97, No. 4, 1992, p. 468-477.

Research output: Contribution to journalArticle

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