Evidence for three tumor suppressor gene loci on chromosome 8p in human prostate cancer

J. A. Macoska, T. M. Trybus, P. D. Benson, W. A. Sakr, D. J. Grignon, K. D. Wojno, David Grignon, I. J. Powell

Research output: Contribution to journalArticle

166 Citations (Scopus)

Abstract

Allelic loss of human chromosome sequences is often equated with inactivation of putative tumor suppressor genes. Loss of sequences on the short arm of chromosome 8 (8p) has been observed in human cancers, especially of 8p22 in prostate tumors. By using PCR analysis of highly polymorphic microsatellite repeat markers at nine 8p loci in 135 tumors, we observed deletion of sequences at 8p22 and at two other proximal deletion domains. These novel deletion domains encompass the NEFL locus and D8S87-ANK1 loci, respectively. These data suggest that three 8p tumor suppressor gene loci may be independently deleted in human prostate cancers.

Original languageEnglish (US)
Pages (from-to)5390-5395
Number of pages6
JournalCancer Research
Volume55
Issue number22
StatePublished - 1995
Externally publishedYes

Fingerprint

Tumor Suppressor Genes
Prostatic Neoplasms
Chromosomes
Microsatellite Repeats
Chromosomes, Human, Pair 8
Neoplasms
Sequence Deletion
Loss of Heterozygosity
Human Chromosomes
Prostate
Polymerase Chain Reaction

ASJC Scopus subject areas

  • Cancer Research
  • Oncology

Cite this

Macoska, J. A., Trybus, T. M., Benson, P. D., Sakr, W. A., Grignon, D. J., Wojno, K. D., ... Powell, I. J. (1995). Evidence for three tumor suppressor gene loci on chromosome 8p in human prostate cancer. Cancer Research, 55(22), 5390-5395.

Evidence for three tumor suppressor gene loci on chromosome 8p in human prostate cancer. / Macoska, J. A.; Trybus, T. M.; Benson, P. D.; Sakr, W. A.; Grignon, D. J.; Wojno, K. D.; Grignon, David; Powell, I. J.

In: Cancer Research, Vol. 55, No. 22, 1995, p. 5390-5395.

Research output: Contribution to journalArticle

Macoska, JA, Trybus, TM, Benson, PD, Sakr, WA, Grignon, DJ, Wojno, KD, Grignon, D & Powell, IJ 1995, 'Evidence for three tumor suppressor gene loci on chromosome 8p in human prostate cancer', Cancer Research, vol. 55, no. 22, pp. 5390-5395.
Macoska JA, Trybus TM, Benson PD, Sakr WA, Grignon DJ, Wojno KD et al. Evidence for three tumor suppressor gene loci on chromosome 8p in human prostate cancer. Cancer Research. 1995;55(22):5390-5395.
Macoska, J. A. ; Trybus, T. M. ; Benson, P. D. ; Sakr, W. A. ; Grignon, D. J. ; Wojno, K. D. ; Grignon, David ; Powell, I. J. / Evidence for three tumor suppressor gene loci on chromosome 8p in human prostate cancer. In: Cancer Research. 1995 ; Vol. 55, No. 22. pp. 5390-5395.
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