Abstract
Objective: Although serum leptin is principally influenced by body mass, to understand the role of insulin and androgens in the regulation of serum leptin in normal weight women. Design: Prospective observational study. Setting: Academic practice in reproductive endocrinology. Patient(s): Twenty- one women with polycystic ovary syndrome (PCOS) of normal body weight, 8 apparently normal women with polycystic-appearing ovaries (PAO), and 21 normal women. Intervention(s): Fasting blood levels of luteinizing hormone, follicle-stimulating hormone, testosterone (T), unbound T, dehydroepiandrosterone sulfate (DHEAS), insulin, insulin growth factor- binding protein-1 (IGFBP-1), and leptin. Main Outcome Measure(s): Comparisons of measured hormones in the different groups and correlative analysis Result(s): Women with PCOS had higher levels of serum luteinizing hormone, T, unbound T, DHEAS and insulin, and lower levels of IGFBP-1 compared with the normal controls, but they had similar leptin levels. Normal women with PAO had increased levels of insulin and leptin compared with controls, whereas IGFBP-1 was lower in PAO. In normal weight women with PCOS and PAO, leptin correlated positively with body weight and insulin, and negatively with IGFBP-1 and DHEAS. Conclusion(s): In normal weight patients serum leptin levels may be regulated in part by insulin. Androgens, on the other hand, may play a role in suppressing serum leptin.
| Original language | English (US) |
|---|---|
| Pages (from-to) | 926-931 |
| Number of pages | 6 |
| Journal | Fertility and Sterility |
| Volume | 72 |
| Issue number | 5 |
| DOIs | |
| State | Published - Nov 1999 |
| Externally published | Yes |
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Keywords
- Adrenal androgens
- Insulin
- Leptin
- PCOS
ASJC Scopus subject areas
- Obstetrics and Gynecology
Cite this
Evidence that insulin and androgens may participate in the regulation of serum leptin levels in women. / Carmina, Enrico; Ferin, Michel; Gonzalez, Frank; Lobo, Rogerio A.
In: Fertility and Sterility, Vol. 72, No. 5, 11.1999, p. 926-931.Research output: Contribution to journal › Article
}
TY - JOUR
T1 - Evidence that insulin and androgens may participate in the regulation of serum leptin levels in women
AU - Carmina, Enrico
AU - Ferin, Michel
AU - Gonzalez, Frank
AU - Lobo, Rogerio A.
PY - 1999/11
Y1 - 1999/11
N2 - Objective: Although serum leptin is principally influenced by body mass, to understand the role of insulin and androgens in the regulation of serum leptin in normal weight women. Design: Prospective observational study. Setting: Academic practice in reproductive endocrinology. Patient(s): Twenty- one women with polycystic ovary syndrome (PCOS) of normal body weight, 8 apparently normal women with polycystic-appearing ovaries (PAO), and 21 normal women. Intervention(s): Fasting blood levels of luteinizing hormone, follicle-stimulating hormone, testosterone (T), unbound T, dehydroepiandrosterone sulfate (DHEAS), insulin, insulin growth factor- binding protein-1 (IGFBP-1), and leptin. Main Outcome Measure(s): Comparisons of measured hormones in the different groups and correlative analysis Result(s): Women with PCOS had higher levels of serum luteinizing hormone, T, unbound T, DHEAS and insulin, and lower levels of IGFBP-1 compared with the normal controls, but they had similar leptin levels. Normal women with PAO had increased levels of insulin and leptin compared with controls, whereas IGFBP-1 was lower in PAO. In normal weight women with PCOS and PAO, leptin correlated positively with body weight and insulin, and negatively with IGFBP-1 and DHEAS. Conclusion(s): In normal weight patients serum leptin levels may be regulated in part by insulin. Androgens, on the other hand, may play a role in suppressing serum leptin.
AB - Objective: Although serum leptin is principally influenced by body mass, to understand the role of insulin and androgens in the regulation of serum leptin in normal weight women. Design: Prospective observational study. Setting: Academic practice in reproductive endocrinology. Patient(s): Twenty- one women with polycystic ovary syndrome (PCOS) of normal body weight, 8 apparently normal women with polycystic-appearing ovaries (PAO), and 21 normal women. Intervention(s): Fasting blood levels of luteinizing hormone, follicle-stimulating hormone, testosterone (T), unbound T, dehydroepiandrosterone sulfate (DHEAS), insulin, insulin growth factor- binding protein-1 (IGFBP-1), and leptin. Main Outcome Measure(s): Comparisons of measured hormones in the different groups and correlative analysis Result(s): Women with PCOS had higher levels of serum luteinizing hormone, T, unbound T, DHEAS and insulin, and lower levels of IGFBP-1 compared with the normal controls, but they had similar leptin levels. Normal women with PAO had increased levels of insulin and leptin compared with controls, whereas IGFBP-1 was lower in PAO. In normal weight women with PCOS and PAO, leptin correlated positively with body weight and insulin, and negatively with IGFBP-1 and DHEAS. Conclusion(s): In normal weight patients serum leptin levels may be regulated in part by insulin. Androgens, on the other hand, may play a role in suppressing serum leptin.
KW - Adrenal androgens
KW - Insulin
KW - Leptin
KW - PCOS
UR - http://www.scopus.com/inward/record.url?scp=0032753252&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=0032753252&partnerID=8YFLogxK
U2 - 10.1016/S0015-0282(99)00387-8
DO - 10.1016/S0015-0282(99)00387-8
M3 - Article
VL - 72
SP - 926
EP - 931
JO - Fertility and Sterility
JF - Fertility and Sterility
SN - 0015-0282
IS - 5
ER -