Evidence that insulin and androgens may participate in the regulation of serum leptin levels in women

Enrico Carmina, Michel Ferin, Frank Gonzalez, Rogerio A. Lobo

Research output: Contribution to journalArticle

38 Citations (Scopus)

Abstract

Objective: Although serum leptin is principally influenced by body mass, to understand the role of insulin and androgens in the regulation of serum leptin in normal weight women. Design: Prospective observational study. Setting: Academic practice in reproductive endocrinology. Patient(s): Twenty- one women with polycystic ovary syndrome (PCOS) of normal body weight, 8 apparently normal women with polycystic-appearing ovaries (PAO), and 21 normal women. Intervention(s): Fasting blood levels of luteinizing hormone, follicle-stimulating hormone, testosterone (T), unbound T, dehydroepiandrosterone sulfate (DHEAS), insulin, insulin growth factor- binding protein-1 (IGFBP-1), and leptin. Main Outcome Measure(s): Comparisons of measured hormones in the different groups and correlative analysis Result(s): Women with PCOS had higher levels of serum luteinizing hormone, T, unbound T, DHEAS and insulin, and lower levels of IGFBP-1 compared with the normal controls, but they had similar leptin levels. Normal women with PAO had increased levels of insulin and leptin compared with controls, whereas IGFBP-1 was lower in PAO. In normal weight women with PCOS and PAO, leptin correlated positively with body weight and insulin, and negatively with IGFBP-1 and DHEAS. Conclusion(s): In normal weight patients serum leptin levels may be regulated in part by insulin. Androgens, on the other hand, may play a role in suppressing serum leptin.

Original languageEnglish (US)
Pages (from-to)926-931
Number of pages6
JournalFertility and Sterility
Volume72
Issue number5
DOIs
StatePublished - Nov 1999
Externally publishedYes

Fingerprint

Leptin
Androgens
Insulin
Serum
Dehydroepiandrosterone Sulfate
Polycystic Ovary Syndrome
Ovary
Intercellular Signaling Peptides and Proteins
Carrier Proteins
Luteinizing Hormone
Weights and Measures
Leptin Receptors
Ideal Body Weight
Endocrinology
Follicle Stimulating Hormone
Observational Studies
Testosterone
Fasting
Body Weight
Outcome Assessment (Health Care)

Keywords

  • Adrenal androgens
  • Insulin
  • Leptin
  • PCOS

ASJC Scopus subject areas

  • Obstetrics and Gynecology

Cite this

Evidence that insulin and androgens may participate in the regulation of serum leptin levels in women. / Carmina, Enrico; Ferin, Michel; Gonzalez, Frank; Lobo, Rogerio A.

In: Fertility and Sterility, Vol. 72, No. 5, 11.1999, p. 926-931.

Research output: Contribution to journalArticle

Carmina, Enrico ; Ferin, Michel ; Gonzalez, Frank ; Lobo, Rogerio A. / Evidence that insulin and androgens may participate in the regulation of serum leptin levels in women. In: Fertility and Sterility. 1999 ; Vol. 72, No. 5. pp. 926-931.
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