Evidence that pediatric liver transplant recipients may undergo late rejection episodes in spite of donor-specific microchimerism

Jean P. Molleston, Yael G. Alevy, Krovvidi S.R. Sivasai, T. Mohanakumar, Todd K. Howard

Research output: Contribution to journalArticle

19 Scopus citations

Abstract

Lymphocytes of donor origin can be demonstrated in the blood of many liver transplant recipients. It has been proposed that this chimerism may imply graft tolerance and permit withdrawal of immunosuppression. We report two children with liver transplants who had lymphocyte chimerism demonstrated at the time of late rejection episodes. One child was chimeric for both of his donors, although he retained the first allograft for only 3 days. Thus, the persistence of donor lymphocytes may be unrelated to the presence of the donor organ. Graft rejection can occur in spite of donor-specific microchimerism. The role of donor-specific microchimerism in graft acceptance or graft tolerance remains to be elucidated.

Original languageEnglish (US)
Pages (from-to)656-657
Number of pages2
JournalTransplantation
Volume61
Issue number4
StatePublished - Feb 27 1996
Externally publishedYes

ASJC Scopus subject areas

  • Transplantation

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