Evidence that RpoS (σS) in Borrelia burgdorferi is controlled directly by RpoN (σ54/σN)

Alexandra H. Smith, Jon S. Blevins, Gulnaz N. Bachlani, X. Yang, Michael V. Norgard

Research output: Contribution to journalArticle

67 Citations (Scopus)

Abstract

The alternative sigma factor (RpoN-RpoS) pathway controls the expression of key virulence factors in Borrelia burgdorferi. However, evidence to support whether RpoN controls rpoS directly or, perhaps, indirectly via a transactivator has been lacking. Herein we provide biochemical and genetic evidence that RpoN directly controls rpoS in B. burgdorferi.

Original languageEnglish
Pages (from-to)2139-2144
Number of pages6
JournalJournal of Bacteriology
Volume189
Issue number5
DOIs
StatePublished - Mar 2007

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Borrelia burgdorferi
Sigma Factor
Trans-Activators
Virulence Factors
Molecular Biology

ASJC Scopus subject areas

  • Applied Microbiology and Biotechnology
  • Immunology

Cite this

Evidence that RpoS (σS) in Borrelia burgdorferi is controlled directly by RpoN (σ54/σN). / Smith, Alexandra H.; Blevins, Jon S.; Bachlani, Gulnaz N.; Yang, X.; Norgard, Michael V.

In: Journal of Bacteriology, Vol. 189, No. 5, 03.2007, p. 2139-2144.

Research output: Contribution to journalArticle

Smith, Alexandra H. ; Blevins, Jon S. ; Bachlani, Gulnaz N. ; Yang, X. ; Norgard, Michael V. / Evidence that RpoS (σS) in Borrelia burgdorferi is controlled directly by RpoN (σ54/σN). In: Journal of Bacteriology. 2007 ; Vol. 189, No. 5. pp. 2139-2144.
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