Evidence versus Practice in Early Drain Removal After Pancreatectomy

Nicole Villafane-Ferriol, Katherine A. Baugh, Amy L. McElhany, George Van Buren, Andrew Fang, Erisha K. Tashakori, Jose E.Mendez Reyes, Hop S.Tran Cao, Eric J. Silberfein, Nader Massarweh, Cary Hsu, Omar Barakat, Carl Schmidt, Nicholas J. Zyromski, Mary Dillhoff, Joshua A. Villarreal, William E. Fisher

Research output: Contribution to journalArticle

1 Scopus citations

Abstract

Background: Early drain removal when postoperative day (POD) one drain fluid amylase (DFA) was ≤5000 U/L reduced complications in a previous randomized controlled trial. We hypothesized that most surgeons continue to remove drains late and this is associated with inferior outcomes. Methods: We assessed the practice of surgeons in a prospectively maintained pancreas surgery registry to determine the association between timing of drain removal with demographics, comorbidities, and complications. We selected patients with POD1 DFA ≤5000 U/L and excluded those without drains, and subjects without data on POD1 DFA or timing of drain removal. Early drain removal was defined as ≤ POD5. Results: Two hundred and forty four patients met inclusion criteria. Only 90 (37%) had drains removed early. Estimated blood loss was greater in the late removal group (190 mL versus 100 mL, P = 0.005) and pathological findings associated with soft gland texture were more frequent (97 [63%] versus 35 [39%], P < 0.0001). Patients in the late drain removal group had more complications (84 [55%] versus 30 [33%], P = 0.001) including pancreatic fistula (55 [36%] versus 4 [4%], P < 0.0001), delayed gastric emptying (27 [18%] versus 3 [3%], P = 0.002), and longer length of stay (7 d versus 5 d, P < 0.0001). In subset analysis for procedure type, complications and pancreatic fistula remained significant for both pancreatoduodenectomy and distal pancreatectomy. Conclusions: Despite level one data suggesting improved outcomes with early removal when POD1 DFA is ≤ 5000 U/L, experienced pancreas surgeons more frequently removed drains late. This practice was associated with known risk factors (estimated blood loss, soft pancreas) and may be associated with inferior outcomes suggesting potential for improvement.

Original languageEnglish (US)
Pages (from-to)332-339
Number of pages8
JournalJournal of Surgical Research
Volume236
DOIs
StatePublished - Apr 2019

Keywords

  • Amylase
  • Distal pancreatectomy
  • Early drain removal
  • Pancreatoduodenectomy

ASJC Scopus subject areas

  • Surgery

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    Villafane-Ferriol, N., Baugh, K. A., McElhany, A. L., Van Buren, G., Fang, A., Tashakori, E. K., Reyes, J. E. M., Cao, H. S. T., Silberfein, E. J., Massarweh, N., Hsu, C., Barakat, O., Schmidt, C., Zyromski, N. J., Dillhoff, M., Villarreal, J. A., & Fisher, W. E. (2019). Evidence versus Practice in Early Drain Removal After Pancreatectomy. Journal of Surgical Research, 236, 332-339. https://doi.org/10.1016/j.jss.2018.11.048