Evoked gamma band response in male adolescent subjects at high risk for alcoholism during a visual oddball task

Ajayan Padmanabhapillai, Yongqiang Tang, Mohini Ranganathan, Madhavi Rangaswamy, Kevin A. Jones, David B. Chorlian, Chella Kamarajan, Arthur Stimus, Samuel Kuperman, John Rohrbaugh, Sean O'Connor, Lance O. Bauer, Marc A. Schuckit, Henri Begleiter, Bernice Porjesz

Research output: Contribution to journalArticle

29 Citations (Scopus)

Abstract

This study investigates early evoked gamma band activity in male adolescent subjects at high risk for alcoholism (HR; n = 68) and normal controls (LR; n = 27) during a visual oddball task. A time-frequency representation method was applied to EEG data in order to obtain stimulus related early evoked (phase-locked) gamma band activity (29-45 Hz) and was analyzed within a 0-150 ms time window range. Significant reduction of the early evoked gamma band response in the frontal and parietal regions during target stimulus processing was observed in HR subjects compared to LR subjects. Additionally, the HR group showed less differentiation between target and non-target stimuli in both frontal and parietal regions compared to the LR group, indicating difficulty in early stimulus processing, probably due to a dysfunctional frontoparietal attentional network. The results indicate that the deficient early evoked gamma band response may precede the development of alcoholism and could be a potential endophenotypic marker of alcoholism risk.

Original languageEnglish
Pages (from-to)262-271
Number of pages10
JournalInternational Journal of Psychophysiology
Volume62
Issue number2
DOIs
StatePublished - Nov 2006

Fingerprint

Alcoholism
Parietal Lobe
Electroencephalography

Keywords

  • Alcoholism
  • Children of alcoholics
  • EEG
  • Event-related oscillations
  • Gamma activity
  • Visual oddball task

ASJC Scopus subject areas

  • Behavioral Neuroscience

Cite this

Padmanabhapillai, A., Tang, Y., Ranganathan, M., Rangaswamy, M., Jones, K. A., Chorlian, D. B., ... Porjesz, B. (2006). Evoked gamma band response in male adolescent subjects at high risk for alcoholism during a visual oddball task. International Journal of Psychophysiology, 62(2), 262-271. https://doi.org/10.1016/j.ijpsycho.2006.05.012

Evoked gamma band response in male adolescent subjects at high risk for alcoholism during a visual oddball task. / Padmanabhapillai, Ajayan; Tang, Yongqiang; Ranganathan, Mohini; Rangaswamy, Madhavi; Jones, Kevin A.; Chorlian, David B.; Kamarajan, Chella; Stimus, Arthur; Kuperman, Samuel; Rohrbaugh, John; O'Connor, Sean; Bauer, Lance O.; Schuckit, Marc A.; Begleiter, Henri; Porjesz, Bernice.

In: International Journal of Psychophysiology, Vol. 62, No. 2, 11.2006, p. 262-271.

Research output: Contribution to journalArticle

Padmanabhapillai, A, Tang, Y, Ranganathan, M, Rangaswamy, M, Jones, KA, Chorlian, DB, Kamarajan, C, Stimus, A, Kuperman, S, Rohrbaugh, J, O'Connor, S, Bauer, LO, Schuckit, MA, Begleiter, H & Porjesz, B 2006, 'Evoked gamma band response in male adolescent subjects at high risk for alcoholism during a visual oddball task', International Journal of Psychophysiology, vol. 62, no. 2, pp. 262-271. https://doi.org/10.1016/j.ijpsycho.2006.05.012
Padmanabhapillai, Ajayan ; Tang, Yongqiang ; Ranganathan, Mohini ; Rangaswamy, Madhavi ; Jones, Kevin A. ; Chorlian, David B. ; Kamarajan, Chella ; Stimus, Arthur ; Kuperman, Samuel ; Rohrbaugh, John ; O'Connor, Sean ; Bauer, Lance O. ; Schuckit, Marc A. ; Begleiter, Henri ; Porjesz, Bernice. / Evoked gamma band response in male adolescent subjects at high risk for alcoholism during a visual oddball task. In: International Journal of Psychophysiology. 2006 ; Vol. 62, No. 2. pp. 262-271.
@article{2215eb3bad8c4f1fbcd9c54a9efd6d0d,
title = "Evoked gamma band response in male adolescent subjects at high risk for alcoholism during a visual oddball task",
abstract = "This study investigates early evoked gamma band activity in male adolescent subjects at high risk for alcoholism (HR; n = 68) and normal controls (LR; n = 27) during a visual oddball task. A time-frequency representation method was applied to EEG data in order to obtain stimulus related early evoked (phase-locked) gamma band activity (29-45 Hz) and was analyzed within a 0-150 ms time window range. Significant reduction of the early evoked gamma band response in the frontal and parietal regions during target stimulus processing was observed in HR subjects compared to LR subjects. Additionally, the HR group showed less differentiation between target and non-target stimuli in both frontal and parietal regions compared to the LR group, indicating difficulty in early stimulus processing, probably due to a dysfunctional frontoparietal attentional network. The results indicate that the deficient early evoked gamma band response may precede the development of alcoholism and could be a potential endophenotypic marker of alcoholism risk.",
keywords = "Alcoholism, Children of alcoholics, EEG, Event-related oscillations, Gamma activity, Visual oddball task",
author = "Ajayan Padmanabhapillai and Yongqiang Tang and Mohini Ranganathan and Madhavi Rangaswamy and Jones, {Kevin A.} and Chorlian, {David B.} and Chella Kamarajan and Arthur Stimus and Samuel Kuperman and John Rohrbaugh and Sean O'Connor and Bauer, {Lance O.} and Schuckit, {Marc A.} and Henri Begleiter and Bernice Porjesz",
year = "2006",
month = "11",
doi = "10.1016/j.ijpsycho.2006.05.012",
language = "English",
volume = "62",
pages = "262--271",
journal = "International Journal of Psychophysiology",
issn = "0167-8760",
publisher = "Elsevier",
number = "2",

}

TY - JOUR

T1 - Evoked gamma band response in male adolescent subjects at high risk for alcoholism during a visual oddball task

AU - Padmanabhapillai, Ajayan

AU - Tang, Yongqiang

AU - Ranganathan, Mohini

AU - Rangaswamy, Madhavi

AU - Jones, Kevin A.

AU - Chorlian, David B.

AU - Kamarajan, Chella

AU - Stimus, Arthur

AU - Kuperman, Samuel

AU - Rohrbaugh, John

AU - O'Connor, Sean

AU - Bauer, Lance O.

AU - Schuckit, Marc A.

AU - Begleiter, Henri

AU - Porjesz, Bernice

PY - 2006/11

Y1 - 2006/11

N2 - This study investigates early evoked gamma band activity in male adolescent subjects at high risk for alcoholism (HR; n = 68) and normal controls (LR; n = 27) during a visual oddball task. A time-frequency representation method was applied to EEG data in order to obtain stimulus related early evoked (phase-locked) gamma band activity (29-45 Hz) and was analyzed within a 0-150 ms time window range. Significant reduction of the early evoked gamma band response in the frontal and parietal regions during target stimulus processing was observed in HR subjects compared to LR subjects. Additionally, the HR group showed less differentiation between target and non-target stimuli in both frontal and parietal regions compared to the LR group, indicating difficulty in early stimulus processing, probably due to a dysfunctional frontoparietal attentional network. The results indicate that the deficient early evoked gamma band response may precede the development of alcoholism and could be a potential endophenotypic marker of alcoholism risk.

AB - This study investigates early evoked gamma band activity in male adolescent subjects at high risk for alcoholism (HR; n = 68) and normal controls (LR; n = 27) during a visual oddball task. A time-frequency representation method was applied to EEG data in order to obtain stimulus related early evoked (phase-locked) gamma band activity (29-45 Hz) and was analyzed within a 0-150 ms time window range. Significant reduction of the early evoked gamma band response in the frontal and parietal regions during target stimulus processing was observed in HR subjects compared to LR subjects. Additionally, the HR group showed less differentiation between target and non-target stimuli in both frontal and parietal regions compared to the LR group, indicating difficulty in early stimulus processing, probably due to a dysfunctional frontoparietal attentional network. The results indicate that the deficient early evoked gamma band response may precede the development of alcoholism and could be a potential endophenotypic marker of alcoholism risk.

KW - Alcoholism

KW - Children of alcoholics

KW - EEG

KW - Event-related oscillations

KW - Gamma activity

KW - Visual oddball task

UR - http://www.scopus.com/inward/record.url?scp=33749149904&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=33749149904&partnerID=8YFLogxK

U2 - 10.1016/j.ijpsycho.2006.05.012

DO - 10.1016/j.ijpsycho.2006.05.012

M3 - Article

C2 - 16887227

AN - SCOPUS:33749149904

VL - 62

SP - 262

EP - 271

JO - International Journal of Psychophysiology

JF - International Journal of Psychophysiology

SN - 0167-8760

IS - 2

ER -