Evoked gamma band response in male adolescent subjects at high risk for alcoholism during a visual oddball task

Ajayan Padmanabhapillai, Yongqiang Tang, Mohini Ranganathan, Madhavi Rangaswamy, Kevin A. Jones, David B. Chorlian, Chella Kamarajan, Arthur Stimus, Samuel Kuperman, John Rohrbaugh, Sean J. O'Connor, Lance O. Bauer, Marc A. Schuckit, Henri Begleiter, Bernice Porjesz

Research output: Contribution to journalArticle

30 Scopus citations

Abstract

This study investigates early evoked gamma band activity in male adolescent subjects at high risk for alcoholism (HR; n = 68) and normal controls (LR; n = 27) during a visual oddball task. A time-frequency representation method was applied to EEG data in order to obtain stimulus related early evoked (phase-locked) gamma band activity (29-45 Hz) and was analyzed within a 0-150 ms time window range. Significant reduction of the early evoked gamma band response in the frontal and parietal regions during target stimulus processing was observed in HR subjects compared to LR subjects. Additionally, the HR group showed less differentiation between target and non-target stimuli in both frontal and parietal regions compared to the LR group, indicating difficulty in early stimulus processing, probably due to a dysfunctional frontoparietal attentional network. The results indicate that the deficient early evoked gamma band response may precede the development of alcoholism and could be a potential endophenotypic marker of alcoholism risk.

Original languageEnglish (US)
Pages (from-to)262-271
Number of pages10
JournalInternational Journal of Psychophysiology
Volume62
Issue number2
DOIs
StatePublished - Nov 1 2006

Keywords

  • Alcoholism
  • Children of alcoholics
  • EEG
  • Event-related oscillations
  • Gamma activity
  • Visual oddball task

ASJC Scopus subject areas

  • Behavioral Neuroscience

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    Padmanabhapillai, A., Tang, Y., Ranganathan, M., Rangaswamy, M., Jones, K. A., Chorlian, D. B., Kamarajan, C., Stimus, A., Kuperman, S., Rohrbaugh, J., O'Connor, S. J., Bauer, L. O., Schuckit, M. A., Begleiter, H., & Porjesz, B. (2006). Evoked gamma band response in male adolescent subjects at high risk for alcoholism during a visual oddball task. International Journal of Psychophysiology, 62(2), 262-271. https://doi.org/10.1016/j.ijpsycho.2006.05.012