Evoked potential changes and neuropsychological performance in Parkinson's disease

Brian O'Donnell, Nancy K. Squires, Merrill J. Martz, Jia Rhon Chen, Andrew J. Phay

Research output: Contribution to journalArticle

99 Citations (Scopus)

Abstract

Auditory brainstem responses (ABRs) and long latency exogenous and endogenous auditory evoked potentials (EPs) were investigated in 16 patients with Parkinson's disease and 11 control subjects. Parkinson's disease patients were impaired on mental status testing. While ABRs and the N1 component of the auditory EP were of normal latency in Parkinson patients, the endogenous components, N2 and P3, were prolonged. Prolongation of P3 latency in Parkinson's disease correlated with mental status decline, but not with severity of motoric disturbance. Thirteen PD patients also received neuropsychological evaluation. P3 latency was correlated with tests requiring learning or mental manipulation of information, but not with measures of verbal performance, immediate memory, or depression. P3 latency prolongation appears to have a selective relationship to intellectual changes in PD, and may be most sensitive to deficits requiring significant cognitive effort.

Original languageEnglish (US)
Pages (from-to)23-37
Number of pages15
JournalBiological Psychology
Volume24
Issue number1
DOIs
StatePublished - 1987
Externally publishedYes

Fingerprint

Evoked Potentials
Parkinson Disease
Auditory Evoked Potentials
Brain Stem Auditory Evoked Potentials
Short-Term Memory
Reaction Time
Learning
Depression

ASJC Scopus subject areas

  • Behavioral Neuroscience
  • Neuropsychology and Physiological Psychology

Cite this

Evoked potential changes and neuropsychological performance in Parkinson's disease. / O'Donnell, Brian; Squires, Nancy K.; Martz, Merrill J.; Chen, Jia Rhon; Phay, Andrew J.

In: Biological Psychology, Vol. 24, No. 1, 1987, p. 23-37.

Research output: Contribution to journalArticle

O'Donnell, Brian ; Squires, Nancy K. ; Martz, Merrill J. ; Chen, Jia Rhon ; Phay, Andrew J. / Evoked potential changes and neuropsychological performance in Parkinson's disease. In: Biological Psychology. 1987 ; Vol. 24, No. 1. pp. 23-37.
@article{3dd10d984ea54f64b8f406aaa63a7f1e,
title = "Evoked potential changes and neuropsychological performance in Parkinson's disease",
abstract = "Auditory brainstem responses (ABRs) and long latency exogenous and endogenous auditory evoked potentials (EPs) were investigated in 16 patients with Parkinson's disease and 11 control subjects. Parkinson's disease patients were impaired on mental status testing. While ABRs and the N1 component of the auditory EP were of normal latency in Parkinson patients, the endogenous components, N2 and P3, were prolonged. Prolongation of P3 latency in Parkinson's disease correlated with mental status decline, but not with severity of motoric disturbance. Thirteen PD patients also received neuropsychological evaluation. P3 latency was correlated with tests requiring learning or mental manipulation of information, but not with measures of verbal performance, immediate memory, or depression. P3 latency prolongation appears to have a selective relationship to intellectual changes in PD, and may be most sensitive to deficits requiring significant cognitive effort.",
author = "Brian O'Donnell and Squires, {Nancy K.} and Martz, {Merrill J.} and Chen, {Jia Rhon} and Phay, {Andrew J.}",
year = "1987",
doi = "10.1016/0301-0511(87)90097-4",
language = "English (US)",
volume = "24",
pages = "23--37",
journal = "Biological Psychology",
issn = "0019-493X",
publisher = "Elsevier",
number = "1",

}

TY - JOUR

T1 - Evoked potential changes and neuropsychological performance in Parkinson's disease

AU - O'Donnell, Brian

AU - Squires, Nancy K.

AU - Martz, Merrill J.

AU - Chen, Jia Rhon

AU - Phay, Andrew J.

PY - 1987

Y1 - 1987

N2 - Auditory brainstem responses (ABRs) and long latency exogenous and endogenous auditory evoked potentials (EPs) were investigated in 16 patients with Parkinson's disease and 11 control subjects. Parkinson's disease patients were impaired on mental status testing. While ABRs and the N1 component of the auditory EP were of normal latency in Parkinson patients, the endogenous components, N2 and P3, were prolonged. Prolongation of P3 latency in Parkinson's disease correlated with mental status decline, but not with severity of motoric disturbance. Thirteen PD patients also received neuropsychological evaluation. P3 latency was correlated with tests requiring learning or mental manipulation of information, but not with measures of verbal performance, immediate memory, or depression. P3 latency prolongation appears to have a selective relationship to intellectual changes in PD, and may be most sensitive to deficits requiring significant cognitive effort.

AB - Auditory brainstem responses (ABRs) and long latency exogenous and endogenous auditory evoked potentials (EPs) were investigated in 16 patients with Parkinson's disease and 11 control subjects. Parkinson's disease patients were impaired on mental status testing. While ABRs and the N1 component of the auditory EP were of normal latency in Parkinson patients, the endogenous components, N2 and P3, were prolonged. Prolongation of P3 latency in Parkinson's disease correlated with mental status decline, but not with severity of motoric disturbance. Thirteen PD patients also received neuropsychological evaluation. P3 latency was correlated with tests requiring learning or mental manipulation of information, but not with measures of verbal performance, immediate memory, or depression. P3 latency prolongation appears to have a selective relationship to intellectual changes in PD, and may be most sensitive to deficits requiring significant cognitive effort.

UR - http://www.scopus.com/inward/record.url?scp=0023102254&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=0023102254&partnerID=8YFLogxK

U2 - 10.1016/0301-0511(87)90097-4

DO - 10.1016/0301-0511(87)90097-4

M3 - Article

VL - 24

SP - 23

EP - 37

JO - Biological Psychology

JF - Biological Psychology

SN - 0019-493X

IS - 1

ER -