Evoked potential changes and neuropsychological performance in Parkinson's disease

Brian F. O'Donnell, Nancy K. Squires, Merrill J. Martz, Jia Rhon Chen, Andrew J. Phay

Research output: Contribution to journalArticle

101 Scopus citations


Auditory brainstem responses (ABRs) and long latency exogenous and endogenous auditory evoked potentials (EPs) were investigated in 16 patients with Parkinson's disease and 11 control subjects. Parkinson's disease patients were impaired on mental status testing. While ABRs and the N1 component of the auditory EP were of normal latency in Parkinson patients, the endogenous components, N2 and P3, were prolonged. Prolongation of P3 latency in Parkinson's disease correlated with mental status decline, but not with severity of motoric disturbance. Thirteen PD patients also received neuropsychological evaluation. P3 latency was correlated with tests requiring learning or mental manipulation of information, but not with measures of verbal performance, immediate memory, or depression. P3 latency prolongation appears to have a selective relationship to intellectual changes in PD, and may be most sensitive to deficits requiring significant cognitive effort.

Original languageEnglish (US)
Pages (from-to)23-37
Number of pages15
JournalBiological Psychology
Issue number1
StatePublished - Feb 1987
Externally publishedYes

ASJC Scopus subject areas

  • Neuroscience(all)
  • Neuropsychology and Physiological Psychology

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