Evolution of tumefactive lesions in multiple sclerosis: A 12-year study with serial imaging in a single patient

Vasiliki N. Ikonomidou, Nancy D. Richert, Alexander Vortmeyer, Fernanda Tovar-Moll, Bibiana Bielekova, Natalie E. Cook, Jeff H. Duyn, Francesca Bagnato

Research output: Contribution to journalArticle

1 Citation (Scopus)

Abstract

We describe the acute presentation and the long-term evolution of recurrent tumefactive lesions (TLs) in a patient with relapsing-remitting multiple sclerosis. Five TLs occurred on three different occasions over a period of 12 years and these were followed by 73 serial magnetic resonance images (MRI). TL evolution was described by means of magnetization transfer imaging (MTI) and cerebrospinal fluid tissue specific imaging (TSI) over the follow-up period. During the study period, the patient had three clinical relapses with only minimal disability progression. MTI demonstrated that only the peripheral portion of each TL reverted to pre-lesional MT ratios within six months' post-enhancement. Recurring TLs may present a similar pattern of evolution that may be associated with a long-term favourable clinical outcome.

Original languageEnglish (US)
Pages (from-to)1539-1543
Number of pages5
JournalMultiple Sclerosis Journal
Volume19
Issue number11
DOIs
StatePublished - Jan 1 2013
Externally publishedYes

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compound A 12
Multiple Sclerosis
Relapsing-Remitting Multiple Sclerosis
Cerebrospinal Fluid
Magnetic Resonance Spectroscopy
Recurrence

Keywords

  • magnetic resonance imaging
  • magnetization transfer imaging
  • Multiple sclerosis
  • recovery
  • tissue-specific imaging
  • tumefactive lesion

ASJC Scopus subject areas

  • Neurology
  • Clinical Neurology

Cite this

Evolution of tumefactive lesions in multiple sclerosis : A 12-year study with serial imaging in a single patient. / Ikonomidou, Vasiliki N.; Richert, Nancy D.; Vortmeyer, Alexander; Tovar-Moll, Fernanda; Bielekova, Bibiana; Cook, Natalie E.; Duyn, Jeff H.; Bagnato, Francesca.

In: Multiple Sclerosis Journal, Vol. 19, No. 11, 01.01.2013, p. 1539-1543.

Research output: Contribution to journalArticle

Ikonomidou, VN, Richert, ND, Vortmeyer, A, Tovar-Moll, F, Bielekova, B, Cook, NE, Duyn, JH & Bagnato, F 2013, 'Evolution of tumefactive lesions in multiple sclerosis: A 12-year study with serial imaging in a single patient', Multiple Sclerosis Journal, vol. 19, no. 11, pp. 1539-1543. https://doi.org/10.1177/1352458513498124
Ikonomidou, Vasiliki N. ; Richert, Nancy D. ; Vortmeyer, Alexander ; Tovar-Moll, Fernanda ; Bielekova, Bibiana ; Cook, Natalie E. ; Duyn, Jeff H. ; Bagnato, Francesca. / Evolution of tumefactive lesions in multiple sclerosis : A 12-year study with serial imaging in a single patient. In: Multiple Sclerosis Journal. 2013 ; Vol. 19, No. 11. pp. 1539-1543.
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