Evolutionary and comparative aspects of nitric oxide, carbon monoxide and hydrogen sulfide

Kenneth Olson, John A. Donald, Ryan A. Dombkowski, Steve F. Perry

Research output: Contribution to journalArticle

59 Citations (Scopus)

Abstract

The concept that non-respiratory gases, such as nitric oxide (NO), carbon monoxide (CO) and hydrogen sulfide (H2S) functioned as signaling moieties is a relatively recent development, due in part to their ephemeral existence in biological tissues. However, from an evolutionary perspective these gases dominated the prebiotic and anoxic Earth and were major contributors to the origin of life and the advent of eukaryotic animals. As Earth's oxygen levels rose, NO, CO and H2S disappeared from the environment and cells began to utilize their now well-developed metabolic pathways to compartmentalize and regulate these three gases for signaling purposes. Ironically, many of the signaling pathways have become now intimately involved in regulating oxygen delivery and their evolution has continued well into the vertebrates. This review examines the role NO, CO and H2S played in early life and their regulatory roles in oxygen delivery during the course of vertebrate evolution.

Original languageEnglish
Pages (from-to)117-129
Number of pages13
JournalRespiratory Physiology and Neurobiology
Volume184
Issue number2
DOIs
StatePublished - Nov 15 2012

Fingerprint

Hydrogen Sulfide
Carbon Monoxide
Nitric Oxide
Gases
Oxygen
Vertebrates
Prebiotics
Metabolic Networks and Pathways
carbon sulfide

Keywords

  • Gasotransmitters
  • Origin of life
  • Origin of mitochondria
  • Oxygen sensing
  • Regulation of respiration

ASJC Scopus subject areas

  • Physiology
  • Pulmonary and Respiratory Medicine
  • Neuroscience(all)

Cite this

Evolutionary and comparative aspects of nitric oxide, carbon monoxide and hydrogen sulfide. / Olson, Kenneth; Donald, John A.; Dombkowski, Ryan A.; Perry, Steve F.

In: Respiratory Physiology and Neurobiology, Vol. 184, No. 2, 15.11.2012, p. 117-129.

Research output: Contribution to journalArticle

Olson, Kenneth ; Donald, John A. ; Dombkowski, Ryan A. ; Perry, Steve F. / Evolutionary and comparative aspects of nitric oxide, carbon monoxide and hydrogen sulfide. In: Respiratory Physiology and Neurobiology. 2012 ; Vol. 184, No. 2. pp. 117-129.
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