Evolving concepts in the pathophysiology of acute pancreatitis

Nicholas Zyromski, Michel M. Murr

Research output: Contribution to journalArticle

49 Citations (Scopus)

Abstract

Our understanding of the pathophysiology of acute pancreatitis has evolved dramatically in recent years. It is now apparent that enzyme-induced, macrophage-derived, extrapancreatic production of cytokines mediates distant organ injury. Future therapies will likely be aimed at 3 targets: prevention of further local pancreatic parenchymal injury, attenuation of macrophage-derived cytokine production, and inhibition of neutrophil-mediated cytotoxicity.

Original languageEnglish (US)
Pages (from-to)235-237
Number of pages3
JournalSurgery
Volume133
Issue number3
DOIs
StatePublished - Mar 1 2003
Externally publishedYes

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Pancreatitis
Macrophages
Cytokines
Wounds and Injuries
Neutrophils
Enzymes
Therapeutics

ASJC Scopus subject areas

  • Surgery

Cite this

Evolving concepts in the pathophysiology of acute pancreatitis. / Zyromski, Nicholas; Murr, Michel M.

In: Surgery, Vol. 133, No. 3, 01.03.2003, p. 235-237.

Research output: Contribution to journalArticle

Zyromski, Nicholas ; Murr, Michel M. / Evolving concepts in the pathophysiology of acute pancreatitis. In: Surgery. 2003 ; Vol. 133, No. 3. pp. 235-237.
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