Evolving concepts in the pathophysiology of acute pancreatitis

Nicholas Zyromski, Michel M. Murr

Research output: Contribution to journalReview article

50 Scopus citations


Our understanding of the pathophysiology of acute pancreatitis has evolved dramatically in recent years. It is now apparent that enzyme-induced, macrophage-derived, extrapancreatic production of cytokines mediates distant organ injury. Future therapies will likely be aimed at 3 targets: prevention of further local pancreatic parenchymal injury, attenuation of macrophage-derived cytokine production, and inhibition of neutrophil-mediated cytotoxicity.

Original languageEnglish (US)
Pages (from-to)235-237
Number of pages3
Issue number3
StatePublished - Mar 1 2003
Externally publishedYes

ASJC Scopus subject areas

  • Surgery

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