Exaggerated norepinephrine-stimulated accumulation of cyclic AMP in vitro in cerebellar slices from pcd mutant mice following Purkinje cell loss

M. J. Schmidt, B. Ghetti

Research output: Contribution to journalArticle

6 Scopus citations

Abstract

Norepinephrine caused in vitro an accumulation of cyclic AMP in slices of the cerebellum from pcd mice which was 300 percent greater than in cerebella from age-matched, heterozygous, normal mice. Purkinje cells had disappeared in the pcd mice at the time when the exaggerated hormonal response was seen. The data indicate that high cyclic AMP accumulation can take place in cerebellar cells other than Purkinje cells.

Original languageEnglish (US)
Pages (from-to)49-56
Number of pages8
JournalJournal of Neural Transmission
Volume48
Issue number1
DOIs
StatePublished - Mar 1 1980

ASJC Scopus subject areas

  • Neurology
  • Clinical Neurology
  • Psychiatry and Mental health
  • Biological Psychiatry

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