Exchange blood transfusion compared with simple transfusion for first overt stroke is associated with a lower risk of subsequent stroke: A retrospective cohort study of 137 children with sickle cell anemia

Monica L. Hulbert, Douglas J. Scothorn, Julie A. Panepinto, J. Paul Scott, George R. Buchanan, Sharada Sarnaik, Robert Fallon, Jen Yih Chu, Winfred Wang, James F. Casella, Linda Resar, Brian Berman, Thomas Adamkiewicz, Lewis L. Hsu, Kimberly Smith-Whitley, Donald Mahoney, Gerald Woods, Masayo Watanabe, Michael R. DeBaun

Research output: Contribution to journalArticle

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Abstract

A retrospective cohort study of children with sickle cell anemia (SCA) and strokes was used to test the hypothesis that exchange transfusion at the time of stroke presentation more effectively prevents second strokes than does simple transfusion. Children receiving simple transfusion had a 5-fold greater relative risk (95% confidence interval = 1.3 to 18.6) of second stroke than those receiving exchange transfusion.

Original languageEnglish (US)
Pages (from-to)710-712
Number of pages3
JournalJournal of Pediatrics
Volume149
Issue number5
DOIs
StatePublished - Nov 2006
Externally publishedYes

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Sickle Cell Anemia
Blood Transfusion
Cohort Studies
Retrospective Studies
Stroke
Confidence Intervals

ASJC Scopus subject areas

  • Pediatrics, Perinatology, and Child Health

Cite this

Exchange blood transfusion compared with simple transfusion for first overt stroke is associated with a lower risk of subsequent stroke : A retrospective cohort study of 137 children with sickle cell anemia. / Hulbert, Monica L.; Scothorn, Douglas J.; Panepinto, Julie A.; Scott, J. Paul; Buchanan, George R.; Sarnaik, Sharada; Fallon, Robert; Chu, Jen Yih; Wang, Winfred; Casella, James F.; Resar, Linda; Berman, Brian; Adamkiewicz, Thomas; Hsu, Lewis L.; Smith-Whitley, Kimberly; Mahoney, Donald; Woods, Gerald; Watanabe, Masayo; DeBaun, Michael R.

In: Journal of Pediatrics, Vol. 149, No. 5, 11.2006, p. 710-712.

Research output: Contribution to journalArticle

Hulbert, ML, Scothorn, DJ, Panepinto, JA, Scott, JP, Buchanan, GR, Sarnaik, S, Fallon, R, Chu, JY, Wang, W, Casella, JF, Resar, L, Berman, B, Adamkiewicz, T, Hsu, LL, Smith-Whitley, K, Mahoney, D, Woods, G, Watanabe, M & DeBaun, MR 2006, 'Exchange blood transfusion compared with simple transfusion for first overt stroke is associated with a lower risk of subsequent stroke: A retrospective cohort study of 137 children with sickle cell anemia', Journal of Pediatrics, vol. 149, no. 5, pp. 710-712. https://doi.org/10.1016/j.jpeds.2006.06.037
Hulbert, Monica L. ; Scothorn, Douglas J. ; Panepinto, Julie A. ; Scott, J. Paul ; Buchanan, George R. ; Sarnaik, Sharada ; Fallon, Robert ; Chu, Jen Yih ; Wang, Winfred ; Casella, James F. ; Resar, Linda ; Berman, Brian ; Adamkiewicz, Thomas ; Hsu, Lewis L. ; Smith-Whitley, Kimberly ; Mahoney, Donald ; Woods, Gerald ; Watanabe, Masayo ; DeBaun, Michael R. / Exchange blood transfusion compared with simple transfusion for first overt stroke is associated with a lower risk of subsequent stroke : A retrospective cohort study of 137 children with sickle cell anemia. In: Journal of Pediatrics. 2006 ; Vol. 149, No. 5. pp. 710-712.
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