Excitatory amino acid receptors in the basolateral amygdala regulate anxiety responses in the social interaction test

T. J. Sajdyk, Anantha Shekhar

Research output: Contribution to journalArticle

84 Citations (Scopus)

Abstract

Blocking GABA(A) receptors in the basolateral amygdala (BLA) elicits increases in heart rate (HR), blood pressure (BP) and anxiety responses by enhancing a glutamate mediated excitation. The present study was conducted to determine the role of the ionotropic glutamate receptors within the BLA in regulating HR, BP and experimental anxiety. Blocking basal glutamate excitation had no significant effect on HR or BP, but did elicit a significant anxiolytic-like effect.

Original languageEnglish
Pages (from-to)262-264
Number of pages3
JournalBrain Research
Volume764
Issue number1-2
DOIs
StatePublished - Aug 1 1997

Fingerprint

Glutamate Receptors
Interpersonal Relations
Anxiety
Heart Rate
Blood Pressure
Glutamic Acid
Ionotropic Glutamate Receptors
Anti-Anxiety Agents
GABA-A Receptors
Basolateral Nuclear Complex

Keywords

  • γ-Aminobutyric acid (GABA)
  • Animal model
  • Blood pressure
  • Glutamate
  • Heart rate
  • N-Methyl-D-aspartate (NMDA)
  • Non-NMDA
  • Panic
  • Stress

ASJC Scopus subject areas

  • Neuroscience(all)

Cite this

Excitatory amino acid receptors in the basolateral amygdala regulate anxiety responses in the social interaction test. / Sajdyk, T. J.; Shekhar, Anantha.

In: Brain Research, Vol. 764, No. 1-2, 01.08.1997, p. 262-264.

Research output: Contribution to journalArticle

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