Excitotoxic effect of kainic acid on chicken cochlear afferent neurons

Marlene Shero, Richard J. Salvi, Lin Chen, Eri Hashino

Research output: Contribution to journalArticle

9 Citations (Scopus)

Abstract

The excitotoxic effects of kainic acid, a glutamate analog, on the auditory neurons in the chicken cochlea were assessed by light and transmission electron microscopy. Kainic acid was directly applied onto the round window of adult chickens and their cochleas were harvested 3 h after application. Transverse microscopic sections of the basilar papilla revealed swelling of afferent dendrites without any morphological changes in efferent endings. The regions of the basilar papilla damaged by kainic acid were localized in the apical 80% and primarily on the neural side where tall hair cells are located. The basal, abneural short hair cell region was devoid of damage. These results imply that glutamate is a primary neurotransmitter in chicken auditory afferent neurons that synapse on tall hair cells.

Original languageEnglish (US)
Pages (from-to)81-84
Number of pages4
JournalNeuroscience Letters
Volume257
Issue number2
DOIs
StatePublished - Nov 27 1998
Externally publishedYes

Fingerprint

Afferent Neurons
Kainic Acid
Cochlea
Organ of Corti
Chickens
Glutamic Acid
Dendrites
Transmission Electron Microscopy
Synapses
Neurotransmitter Agents
Neurons
Light

Keywords

  • Afferent neuron
  • Chicken
  • Cochlea
  • Excitotoxicity
  • Glutamate
  • Kainic acid

ASJC Scopus subject areas

  • Neuroscience(all)

Cite this

Excitotoxic effect of kainic acid on chicken cochlear afferent neurons. / Shero, Marlene; Salvi, Richard J.; Chen, Lin; Hashino, Eri.

In: Neuroscience Letters, Vol. 257, No. 2, 27.11.1998, p. 81-84.

Research output: Contribution to journalArticle

Shero, Marlene ; Salvi, Richard J. ; Chen, Lin ; Hashino, Eri. / Excitotoxic effect of kainic acid on chicken cochlear afferent neurons. In: Neuroscience Letters. 1998 ; Vol. 257, No. 2. pp. 81-84.
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