Exercise can reverse the phenotype of Biglycan deficient mice

Joseph M. Wallace, Rupak M. Rajachar, Xiao Dong Chen, Songtao Shi, Matthew Allen, Susan A. Bloomfield, Pamela G. Robey, Marian F. Young, David H. Kohn

Research output: Chapter in Book/Report/Conference proceedingConference contribution

Abstract

Biglycan (Bgn) is a small leucine-rich proteoglycan (SLRP) that is enriched in bone and other skeletal connective tissues and is responsible, in part, for the regulation of postnatal skeletal growth (Bianco, 1990). Mice lacking Bgn display reduced skeletal development and a lower peak bone mass that leads to age-dependent osteopenia (Xu, 1998). We hypothesized that mechanical loading could reverse the skeletal phenotype of Bgn knockout mice. To test this hypothesis, we determined the effects of treadmill running on the geometric, mechanical and mineral properties of Bgn deficient mice bones. After sacrifice, femora and tibiae were tested in 4 point bending and cross-sectional geometric properties and bone mineral parameters were measured. Exercise was able to partially reverse the skeletal phenotype of the Bgn knockouts by increasing both the geometric and mechanical properties of the tibiae to values equal to or greater than those of wild type control mice.

Original languageEnglish (US)
Title of host publicationAmerican Society of Mechanical Engineers, Bioengineering Division (Publication) BED
PublisherAmerican Society of Mechanical Engineers (ASME)
Pages37-38
Number of pages2
Volume55
DOIs
StatePublished - 2003
Externally publishedYes
Event2003 ASME International Mechanical Engineering Congress - Washington, DC., United States
Duration: Nov 15 2003Nov 21 2003

Other

Other2003 ASME International Mechanical Engineering Congress
CountryUnited States
CityWashington, DC.
Period11/15/0311/21/03

Fingerprint

Bone
Minerals
Exercise equipment
Display devices
Tissue
Mechanical properties

ASJC Scopus subject areas

  • Engineering(all)

Cite this

Wallace, J. M., Rajachar, R. M., Chen, X. D., Shi, S., Allen, M., Bloomfield, S. A., ... Kohn, D. H. (2003). Exercise can reverse the phenotype of Biglycan deficient mice. In American Society of Mechanical Engineers, Bioengineering Division (Publication) BED (Vol. 55, pp. 37-38). American Society of Mechanical Engineers (ASME). https://doi.org/10.1115/IMECE2003-43116

Exercise can reverse the phenotype of Biglycan deficient mice. / Wallace, Joseph M.; Rajachar, Rupak M.; Chen, Xiao Dong; Shi, Songtao; Allen, Matthew; Bloomfield, Susan A.; Robey, Pamela G.; Young, Marian F.; Kohn, David H.

American Society of Mechanical Engineers, Bioengineering Division (Publication) BED. Vol. 55 American Society of Mechanical Engineers (ASME), 2003. p. 37-38.

Research output: Chapter in Book/Report/Conference proceedingConference contribution

Wallace, JM, Rajachar, RM, Chen, XD, Shi, S, Allen, M, Bloomfield, SA, Robey, PG, Young, MF & Kohn, DH 2003, Exercise can reverse the phenotype of Biglycan deficient mice. in American Society of Mechanical Engineers, Bioengineering Division (Publication) BED. vol. 55, American Society of Mechanical Engineers (ASME), pp. 37-38, 2003 ASME International Mechanical Engineering Congress, Washington, DC., United States, 11/15/03. https://doi.org/10.1115/IMECE2003-43116
Wallace JM, Rajachar RM, Chen XD, Shi S, Allen M, Bloomfield SA et al. Exercise can reverse the phenotype of Biglycan deficient mice. In American Society of Mechanical Engineers, Bioengineering Division (Publication) BED. Vol. 55. American Society of Mechanical Engineers (ASME). 2003. p. 37-38 https://doi.org/10.1115/IMECE2003-43116
Wallace, Joseph M. ; Rajachar, Rupak M. ; Chen, Xiao Dong ; Shi, Songtao ; Allen, Matthew ; Bloomfield, Susan A. ; Robey, Pamela G. ; Young, Marian F. ; Kohn, David H. / Exercise can reverse the phenotype of Biglycan deficient mice. American Society of Mechanical Engineers, Bioengineering Division (Publication) BED. Vol. 55 American Society of Mechanical Engineers (ASME), 2003. pp. 37-38
@inproceedings{012a14220ace4b0a9af768065fdaa490,
title = "Exercise can reverse the phenotype of Biglycan deficient mice",
abstract = "Biglycan (Bgn) is a small leucine-rich proteoglycan (SLRP) that is enriched in bone and other skeletal connective tissues and is responsible, in part, for the regulation of postnatal skeletal growth (Bianco, 1990). Mice lacking Bgn display reduced skeletal development and a lower peak bone mass that leads to age-dependent osteopenia (Xu, 1998). We hypothesized that mechanical loading could reverse the skeletal phenotype of Bgn knockout mice. To test this hypothesis, we determined the effects of treadmill running on the geometric, mechanical and mineral properties of Bgn deficient mice bones. After sacrifice, femora and tibiae were tested in 4 point bending and cross-sectional geometric properties and bone mineral parameters were measured. Exercise was able to partially reverse the skeletal phenotype of the Bgn knockouts by increasing both the geometric and mechanical properties of the tibiae to values equal to or greater than those of wild type control mice.",
author = "Wallace, {Joseph M.} and Rajachar, {Rupak M.} and Chen, {Xiao Dong} and Songtao Shi and Matthew Allen and Bloomfield, {Susan A.} and Robey, {Pamela G.} and Young, {Marian F.} and Kohn, {David H.}",
year = "2003",
doi = "10.1115/IMECE2003-43116",
language = "English (US)",
volume = "55",
pages = "37--38",
booktitle = "American Society of Mechanical Engineers, Bioengineering Division (Publication) BED",
publisher = "American Society of Mechanical Engineers (ASME)",

}

TY - GEN

T1 - Exercise can reverse the phenotype of Biglycan deficient mice

AU - Wallace, Joseph M.

AU - Rajachar, Rupak M.

AU - Chen, Xiao Dong

AU - Shi, Songtao

AU - Allen, Matthew

AU - Bloomfield, Susan A.

AU - Robey, Pamela G.

AU - Young, Marian F.

AU - Kohn, David H.

PY - 2003

Y1 - 2003

N2 - Biglycan (Bgn) is a small leucine-rich proteoglycan (SLRP) that is enriched in bone and other skeletal connective tissues and is responsible, in part, for the regulation of postnatal skeletal growth (Bianco, 1990). Mice lacking Bgn display reduced skeletal development and a lower peak bone mass that leads to age-dependent osteopenia (Xu, 1998). We hypothesized that mechanical loading could reverse the skeletal phenotype of Bgn knockout mice. To test this hypothesis, we determined the effects of treadmill running on the geometric, mechanical and mineral properties of Bgn deficient mice bones. After sacrifice, femora and tibiae were tested in 4 point bending and cross-sectional geometric properties and bone mineral parameters were measured. Exercise was able to partially reverse the skeletal phenotype of the Bgn knockouts by increasing both the geometric and mechanical properties of the tibiae to values equal to or greater than those of wild type control mice.

AB - Biglycan (Bgn) is a small leucine-rich proteoglycan (SLRP) that is enriched in bone and other skeletal connective tissues and is responsible, in part, for the regulation of postnatal skeletal growth (Bianco, 1990). Mice lacking Bgn display reduced skeletal development and a lower peak bone mass that leads to age-dependent osteopenia (Xu, 1998). We hypothesized that mechanical loading could reverse the skeletal phenotype of Bgn knockout mice. To test this hypothesis, we determined the effects of treadmill running on the geometric, mechanical and mineral properties of Bgn deficient mice bones. After sacrifice, femora and tibiae were tested in 4 point bending and cross-sectional geometric properties and bone mineral parameters were measured. Exercise was able to partially reverse the skeletal phenotype of the Bgn knockouts by increasing both the geometric and mechanical properties of the tibiae to values equal to or greater than those of wild type control mice.

UR - http://www.scopus.com/inward/record.url?scp=1842614111&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=1842614111&partnerID=8YFLogxK

U2 - 10.1115/IMECE2003-43116

DO - 10.1115/IMECE2003-43116

M3 - Conference contribution

AN - SCOPUS:1842614111

VL - 55

SP - 37

EP - 38

BT - American Society of Mechanical Engineers, Bioengineering Division (Publication) BED

PB - American Society of Mechanical Engineers (ASME)

ER -