Exercise capacity and haemodynamics in patients with sickle cell disease with pulmonary hypertension treated with bosentan: Results of the ASSET studies

Robyn J. Barst, Kamal K. Mubarak, Roberto F. MacHado, Kenneth I. Ataga, Raymond L. Benza, Oswaldo Castro, Robert Naeije, Namita Sood, Paul S. Swerdlow, Mariana Hildesheim, Mark T. Gladwin

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Abstract

Doppler-defined pulmonary hypertension (PH) in sickle cell disease (SCD) is associated with 40% mortality at 40 months. To assess the effect of bosentan in SCD-PH, two randomized, double-blind, placebo-controlled, 16-week studies were initiated. Safety concerns are particularly relevant in SCD due to comorbid conditions. ASSET-1 and -2 enrolled patients with pulmonary arterial hypertension (PAH) and pulmonary venous hypertension (PH), respectively. Haemodynamics and 6-min walk distance (6MWD) were obtained at baseline and week 16. The studies were terminated due to slow site initiation and patient enrolment (n = 26). Bosentan appeared to be well tolerated. Although sample sizes were limited, in ASSET-1 at baseline, 6MWD correlated with cardiac output (CO; P = 0·006) with non-significant inverse correlations between 6MWD and pulmonary vascular resistance (PVR; P = 0·07) and between 6MWD and right atrial pressure (P = 0·08). In ASSET-2 at baseline, there was a non-significant correlation between 6MWD and CO (P = 0·06). Due to limited sample sizes, efficacy endpoints were not analysed. However, in both studies, non-significant increases in CO were observed with bosentan compared to placebo. Similarly, non-significant decreases in PVR were observed with bosentan. Limited data in SCD-PH suggest that a low 6MWD predicts a low CO. Standard-dose bosentan appears to be well tolerated. Further investigation is warranted. Clinicaltrials.gov registration numbers NCT00310830, NCT00313196, NCT00360087.

Original languageEnglish (US)
Pages (from-to)426-435
Number of pages10
JournalBritish journal of haematology
Volume149
Issue number3
DOIs
StatePublished - May 1 2010

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Keywords

  • Endothelin receptor antagonism
  • Exercise capacity
  • Haemodynamics
  • Pulmonary hypertension
  • Sickle cell anaemia

ASJC Scopus subject areas

  • Hematology

Cite this

Barst, R. J., Mubarak, K. K., MacHado, R. F., Ataga, K. I., Benza, R. L., Castro, O., Naeije, R., Sood, N., Swerdlow, P. S., Hildesheim, M., & Gladwin, M. T. (2010). Exercise capacity and haemodynamics in patients with sickle cell disease with pulmonary hypertension treated with bosentan: Results of the ASSET studies. British journal of haematology, 149(3), 426-435. https://doi.org/10.1111/j.1365-2141.2010.08097.x