Exercise capacity of mice genetically lacking muscle glycogen synthase: In mice, muscle glycogen is not essential for exercise

Bartholomew A. Pederson, Carlie M. Cope, Jill M. Schroeder, Micah W. Smith, José M. Irimia, Beth L. Thurberg, Anna A. DePaoli-Roach, Peter J. Roach

Research output: Contribution to journalArticle

72 Citations (Scopus)

Abstract

The glucose storage polymer glycogen is generally considered to be an important source of energy for skeletal muscle contraction and a factor in exercise endurance. A genetically modified mouse model lacking muscle glycogen was used to examine whether the absence of the polysaccharide affects the ability of mice to run on a treadmill. The MGSKO mouse has the GFS1 gene, encoding the muscle isoform of glycogen synthase, disrupted so that skeletal muscle totally lacks glycogen. The morphology of the soleus and quadriceps muscles from MGSKO mice appeared normal. MGSKO-null mice, along with wild type littermates, were exercised to exhaustion. There were no significant differences in the work performed by MGSKO mice as compared with their wild type littermates. The amount of liver glycogen consumed during exercise was similar for MGSKO and wild type animals. Fasting reduced exercise endurance, and after overnight fasting, there was a trend to reduced exercise endurance for the MGSKO mice. These studies provide genetic evidence that in mice muscle glycogen is not essential for strenuous exercise and has relatively little effect on endurance.

Original languageEnglish (US)
Pages (from-to)17260-17265
Number of pages6
JournalJournal of Biological Chemistry
Volume280
Issue number17
DOIs
StatePublished - Apr 29 2005

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Glycogen Synthase
Glycogen
Muscle
Muscles
Durability
Skeletal Muscle
Fasting
Exercise equipment
Liver Glycogen
Gene encoding
Aptitude
Wild Animals
Polysaccharides
Glucans
Quadriceps Muscle
Polymers
Protein Isoforms
Animals
Muscle Contraction
Glucose

ASJC Scopus subject areas

  • Biochemistry
  • Molecular Biology
  • Cell Biology

Cite this

Exercise capacity of mice genetically lacking muscle glycogen synthase : In mice, muscle glycogen is not essential for exercise. / Pederson, Bartholomew A.; Cope, Carlie M.; Schroeder, Jill M.; Smith, Micah W.; Irimia, José M.; Thurberg, Beth L.; DePaoli-Roach, Anna A.; Roach, Peter J.

In: Journal of Biological Chemistry, Vol. 280, No. 17, 29.04.2005, p. 17260-17265.

Research output: Contribution to journalArticle

Pederson, Bartholomew A. ; Cope, Carlie M. ; Schroeder, Jill M. ; Smith, Micah W. ; Irimia, José M. ; Thurberg, Beth L. ; DePaoli-Roach, Anna A. ; Roach, Peter J. / Exercise capacity of mice genetically lacking muscle glycogen synthase : In mice, muscle glycogen is not essential for exercise. In: Journal of Biological Chemistry. 2005 ; Vol. 280, No. 17. pp. 17260-17265.
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