Exercise echocardiography, angioqraphy, and intracoronary ultrasound after cardiac transplantation

Joel M. Cohn, Robert L. Wilensky, Jacqueline O'Donnell, Patrick D V Bourdillon, James C. Dillon, Harvey Feigenbaum

Research output: Contribution to journalArticle

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Abstract

Fifty-one consecutive patients underwent exercise echocardiography, angiography, and intracoronary ultrasound (ICUS) 2.5 years (range 1 to 6) after cardiac transplantation. The average age of the donor was 29 years (range 13 to 50), and the average age of the recipient was 49 ± 12 years. In total, 78 studies were performed, as 25 patients had > 1 annual evaluation and 2 patients had 3 consecutive annual evaluations. Of the 78 angiographic studies, 40 (26 patients) had evidence of coronary artery disease, defined as a focal stenosis (>20%, n = 4) or luminal irregularities (n = 36). However, by ICUS all 51 patients had intimai thickening at some point, with 34 patients possessing diffuse disease and 17 focal intimal thickening only. Of the 25 serial studies, 12 progressed by at least 1 Stanford class. The sensitivity of angiography for the determination of class III to IV intimal thickening was 64%, and the specificity was 76%. On exercise echocardiography, 6 examinations revealed resting wall motion abnormalities, whereas 6 had inducible wall motion abnormalities with exercise. The sensitivity of exercise echocardiography to determine class III to IV intimai thickening was 15%, and the specificity was 85%. In conclusion, exercise echocardiography is an insensitive method for predicting transplant-mediated coronary artery disease, whereas luminal irregularities on angiography may predict the presence of Stanford grade III to IV intimai thickening.

Original languageEnglish
Pages (from-to)1216-1219
Number of pages4
JournalThe American Journal of Cardiology
Volume77
Issue number14
DOIs
StatePublished - Jun 1 1996

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Heart Transplantation
Echocardiography
Exercise
Tunica Intima
Angiography
Coronary Artery Disease
Pathologic Constriction
Tissue Donors
Transplants

ASJC Scopus subject areas

  • Cardiology and Cardiovascular Medicine

Cite this

Exercise echocardiography, angioqraphy, and intracoronary ultrasound after cardiac transplantation. / Cohn, Joel M.; Wilensky, Robert L.; O'Donnell, Jacqueline; Bourdillon, Patrick D V; Dillon, James C.; Feigenbaum, Harvey.

In: The American Journal of Cardiology, Vol. 77, No. 14, 01.06.1996, p. 1216-1219.

Research output: Contribution to journalArticle

Cohn, Joel M. ; Wilensky, Robert L. ; O'Donnell, Jacqueline ; Bourdillon, Patrick D V ; Dillon, James C. ; Feigenbaum, Harvey. / Exercise echocardiography, angioqraphy, and intracoronary ultrasound after cardiac transplantation. In: The American Journal of Cardiology. 1996 ; Vol. 77, No. 14. pp. 1216-1219.
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