Exercise training effects on collateral and microvascular resistances in rat model of arterial insufficiency

J. M. Lash, J. C. Nixon, J. L. Unthank

Research output: Contribution to journalArticle

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Abstract

Experiments were performed to determine if exercise training reduces collateral or microvascular resistances in the hindlimb of rats with arterial insufficiency. After right femoral arterial ligation (age 10 wk), rats were divided into sedentary (Sed) and treadmill-trained (Tr) groups (7-9 wk, final intensity: 27 m/min, 6° grade, 60 min/day). Minimal resistances (mmHg · ml-1 · min · 100 g) of the total limb (RT), collateral vessels (Rc), and the microcirculations distal (R(fmc)) and proximal (R(imc)) to the ligation site were determined during pump perfusion of the hindlimbs. R(T) was lower in nonligated (open) and acutely ligated limbs of Tr than Sed rats (open: 0.69 ± 0.011 vs. 0.93 ± 0.071; acute: 0.92 ± 0.028 vs. 1.18 ± 0.070 mmHg · ml-1 · min · 100 g) but not in chronically ligated limbs (chronic: 0.88 ± 0.072 vs. 1.00 ± 0.046 mmHg · ml-1 · min · 100 g). R(C) was similar between the chronically ligated limbs of Sed and Tr rats (1.69 ± 0.165 vs. 1.97 ± 0.227 mmHg · ml-1 · min · 100 g) and was ~70% lower than in acutely ligated limbs of both groups. R(fmc) and R(imc) were not affected by arterial ligation, but R(imc) was significantly lower in Tr than in Sed rats (acute: 1.05 ± 0.026 vs. 1.54 ± 0.163; chronic: 1.24 ± 0.071 vs. 1.81 ± 0.202 mmHg · ml-1 · min · 100 g). These results indicate that the primary site of vascular adaptations to chronic arterial ligation is in the collateral vessels. Exercise training does not significantly alter the collateralization process but may provide protection against acute arterial occlusion by stimulating microvascular growth.

Original languageEnglish
JournalAmerican Journal of Physiology - Heart and Circulatory Physiology
Volume268
Issue number1 37-1
StatePublished - 1995

Fingerprint

limbs (animal)
exercise
Extremities
animal models
Ligation
Exercise
rats
Hindlimb
Infusion Pumps
exercise equipment
thighs
Microcirculation
Thigh
blood vessels
pumps
Blood Vessels
Growth
hindlimbs

ASJC Scopus subject areas

  • Physiology
  • Agricultural and Biological Sciences(all)

Cite this

Exercise training effects on collateral and microvascular resistances in rat model of arterial insufficiency. / Lash, J. M.; Nixon, J. C.; Unthank, J. L.

In: American Journal of Physiology - Heart and Circulatory Physiology, Vol. 268, No. 1 37-1, 1995.

Research output: Contribution to journalArticle

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abstract = "Experiments were performed to determine if exercise training reduces collateral or microvascular resistances in the hindlimb of rats with arterial insufficiency. After right femoral arterial ligation (age 10 wk), rats were divided into sedentary (Sed) and treadmill-trained (Tr) groups (7-9 wk, final intensity: 27 m/min, 6° grade, 60 min/day). Minimal resistances (mmHg · ml-1 · min · 100 g) of the total limb (RT), collateral vessels (Rc), and the microcirculations distal (R(fmc)) and proximal (R(imc)) to the ligation site were determined during pump perfusion of the hindlimbs. R(T) was lower in nonligated (open) and acutely ligated limbs of Tr than Sed rats (open: 0.69 ± 0.011 vs. 0.93 ± 0.071; acute: 0.92 ± 0.028 vs. 1.18 ± 0.070 mmHg · ml-1 · min · 100 g) but not in chronically ligated limbs (chronic: 0.88 ± 0.072 vs. 1.00 ± 0.046 mmHg · ml-1 · min · 100 g). R(C) was similar between the chronically ligated limbs of Sed and Tr rats (1.69 ± 0.165 vs. 1.97 ± 0.227 mmHg · ml-1 · min · 100 g) and was ~70{\%} lower than in acutely ligated limbs of both groups. R(fmc) and R(imc) were not affected by arterial ligation, but R(imc) was significantly lower in Tr than in Sed rats (acute: 1.05 ± 0.026 vs. 1.54 ± 0.163; chronic: 1.24 ± 0.071 vs. 1.81 ± 0.202 mmHg · ml-1 · min · 100 g). These results indicate that the primary site of vascular adaptations to chronic arterial ligation is in the collateral vessels. Exercise training does not significantly alter the collateralization process but may provide protection against acute arterial occlusion by stimulating microvascular growth.",
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