Exhaled breath condensate purines correlate with lung function in infants and preschoolers

Kavita Patel, Stephanie Davis, Robin Johnson, Charles R. Esther

Research output: Contribution to journalArticle

16 Citations (Scopus)

Abstract

Rationale Although airway inflammation begins early in life in children with chronic respiratory diseases, current methods to assess this inflammation are invasive and entail significant risk. Measurement of exhaled breath condensate (EBC) purines and other biomarkers offers a less invasive method to assess airway inflammation; however, the feasibility and utility of EBC biomarkers in young children has not been established. Methods EBC was collected from children 0.5, r = -0.71, P <0.01) and positively with the ratio of residual volume to total lung capacity (RV/TLC, r = 0.66, P = 0.015). These correlations remained statistically significant in the subset with CF. Conclusions EBC can be safely collected and analyzed in preschool children using commercially available equipment. The EBC AMP/Ado ratio correlates with measures of infant lung function and may be a less invasive means of monitoring airway inflammation in this population. Pediatr Pulmonol. 2013; 48:182-187. © 2012 Wiley Periodicals, Inc.

Original languageEnglish (US)
Pages (from-to)182-187
Number of pages6
JournalPediatric Pulmonology
Volume48
Issue number2
DOIs
StatePublished - Feb 2013
Externally publishedYes

Fingerprint

Purines
Inflammation
Lung
Biomarkers
Total Lung Capacity
Residual Volume
Preschool Children
Adenosine Monophosphate
Chronic Disease
Equipment and Supplies
Population

Keywords

  • adenosine
  • adenosine monophosphate
  • infant pulmonary function testing
  • mass spectrometry

ASJC Scopus subject areas

  • Pediatrics, Perinatology, and Child Health
  • Pulmonary and Respiratory Medicine

Cite this

Exhaled breath condensate purines correlate with lung function in infants and preschoolers. / Patel, Kavita; Davis, Stephanie; Johnson, Robin; Esther, Charles R.

In: Pediatric Pulmonology, Vol. 48, No. 2, 02.2013, p. 182-187.

Research output: Contribution to journalArticle

Patel, Kavita ; Davis, Stephanie ; Johnson, Robin ; Esther, Charles R. / Exhaled breath condensate purines correlate with lung function in infants and preschoolers. In: Pediatric Pulmonology. 2013 ; Vol. 48, No. 2. pp. 182-187.
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