Exogenous cushing syndrome mimicking human immunodeficiency virus lipodystrophy.

Samir K. Gupta, Michael P. Dubé

Research output: Contribution to journalArticle

36 Scopus citations


A 45-year-old man infected with human immunodeficiency virus (HIV) developed abnormal fat accumulations that initially were believed to be caused by HIV lipodystrophy. Further clinical evaluation revealed, however, that the patient had developed exogenous Cushing syndrome, which presumably was caused by the inhibition of CYP3A4's metabolism of inhaled fluticasone by the protease inhibitor ritonavir. Clinicians should be aware that clinical clues may indicate conditions other than lipodystrophy that may cause abnormal fat accumulation and that fluticasone should be cautiously administered to patients who are receiving ritonavir.

Original languageEnglish (US)
Pages (from-to)E69-71
JournalClinical infectious diseases : an official publication of the Infectious Diseases Society of America
Issue number6
StatePublished - Sep 15 2002

ASJC Scopus subject areas

  • Microbiology (medical)
  • Infectious Diseases

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