Exogenous endothelial cells as accelerators of hematopoietic reconstitution

J. C. Mizer, Thomas E. Ichim, Doru T. Alexandrescu, Constantin A. Dasanu, Famela Ramos, Andrew Turner, Erik J. Woods, Vladimir Bogin, Michael P. Murphy, David Koos, Amit N. Patel

Research output: Contribution to journalReview articlepeer-review

2 Scopus citations

Abstract

Despite the successes of recombinant hematopoietic-stimulatory factors at accelerating bone marrow reconstitution and shortening the neutropenic period post-transplantation, significant challenges remain such as cost, inability to reconstitute thrombocytic lineages, and lack of efficacy in conditions such as aplastic anemia. A possible means of accelerating hematopoietic reconstitution would be administration of cells capable of secreting hematopoietic growth factors. Advantages of this approach would include: a) ability to regulate secretion of cytokines based on biological need; b) long term, localized production of growth factors, alleviating need for systemic administration of factors that possess unintended adverse effects; and c) potential to actively repair the hematopoietic stem cell niche. Here we overview the field of hematopoietic growth factors, discuss previous experiences with mesenchymal stem cells (MSC) in accelerating hematopoiesis, and conclude by putting forth the rationale of utilizing exogenous endothelial cells as a novel cellular therapy for acceleration of hematopoietic recovery.

Original languageEnglish (US)
Article number231
JournalJournal of Translational Medicine
Volume10
Issue number1
DOIs
StatePublished - Nov 21 2012

ASJC Scopus subject areas

  • Biochemistry, Genetics and Molecular Biology(all)

Fingerprint Dive into the research topics of 'Exogenous endothelial cells as accelerators of hematopoietic reconstitution'. Together they form a unique fingerprint.

Cite this