Exosomes from retinal astrocytes contain antiangiogenic components that inhibit laser-induced choroidal neovascularization

Amir Reza Hajrasouliha, Guomin Jiang, Qingxian Lu, Huayi Lu, Henry J. Kaplan, Huang Ge Zhang, Hui Shao

Research output: Contribution to journalArticle

39 Citations (Scopus)

Abstract

Background: It is unknown whether the exosomes derived from neurosensory retinal cells regulate angiogenesis in the eye. Results: Exosomes from retinal astrocytes contain multiple antiangiogenic components that inhibit laser-induced choroidal neovascularization. Conclusion: Exosomes from monolayer culture of retinal astrocytes, but not retinal pigment epithelium, are antiangiogenic. Significance: Retinal astrocyte exosomes might be a potential for clinical applications in the treatment of choroidal neovascularization.

Original languageEnglish (US)
Pages (from-to)28058-28067
Number of pages10
JournalJournal of Biological Chemistry
Volume288
Issue number39
DOIs
StatePublished - Sep 27 2013

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Exosomes
Choroidal Neovascularization
Astrocytes
Lasers
Retinal Pigments
Retinal Pigment Epithelium
Monolayers
Cells

ASJC Scopus subject areas

  • Biochemistry
  • Molecular Biology
  • Cell Biology

Cite this

Exosomes from retinal astrocytes contain antiangiogenic components that inhibit laser-induced choroidal neovascularization. / Hajrasouliha, Amir Reza; Jiang, Guomin; Lu, Qingxian; Lu, Huayi; Kaplan, Henry J.; Zhang, Huang Ge; Shao, Hui.

In: Journal of Biological Chemistry, Vol. 288, No. 39, 27.09.2013, p. 28058-28067.

Research output: Contribution to journalArticle

Hajrasouliha, Amir Reza ; Jiang, Guomin ; Lu, Qingxian ; Lu, Huayi ; Kaplan, Henry J. ; Zhang, Huang Ge ; Shao, Hui. / Exosomes from retinal astrocytes contain antiangiogenic components that inhibit laser-induced choroidal neovascularization. In: Journal of Biological Chemistry. 2013 ; Vol. 288, No. 39. pp. 28058-28067.
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