Exosomes from retinal astrocytes contain antiangiogenic components that inhibit laser-induced choroidal neovascularization

Amir Reza Hajrasouliha, Guomin Jiang, Qingxian Lu, Huayi Lu, Henry J. Kaplan, Huang Ge Zhang, Hui Shao

Research output: Contribution to journalArticle

45 Scopus citations

Abstract

Background: It is unknown whether the exosomes derived from neurosensory retinal cells regulate angiogenesis in the eye. Results: Exosomes from retinal astrocytes contain multiple antiangiogenic components that inhibit laser-induced choroidal neovascularization. Conclusion: Exosomes from monolayer culture of retinal astrocytes, but not retinal pigment epithelium, are antiangiogenic. Significance: Retinal astrocyte exosomes might be a potential for clinical applications in the treatment of choroidal neovascularization.

Original languageEnglish (US)
Pages (from-to)28058-28067
Number of pages10
JournalJournal of Biological Chemistry
Volume288
Issue number39
DOIs
StatePublished - Sep 27 2013
Externally publishedYes

ASJC Scopus subject areas

  • Biochemistry
  • Molecular Biology
  • Cell Biology

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