Experimental infection of young specific pathogen-free cats with Bartonella henselae

Lynn Guptill, Leonard Slater, Ching Ching Wu, Tsang Long Lin, Lawrence T. Glickman, David F. Welch, Harm HogenEsch

Research output: Contribution to journalArticle

126 Scopus citations


Eighteen 12-week-old specific pathogen-free cats, blood culture- and serum antibody-negative for Bartonella henselae, were randomly allocated to groups and were intravenously inoculated with 1010 (group 1), 108 (group 2), or 106 (group 3) B. henselae or with saline (group 4) or were not inoculated (group 5). Cats were humanely killed at 2, 4, 8, 16, and 32 weeks after inoculation. All B. henselae-inoculated cats were bacteremic by 2 weeks after infection. Bacteremia persisted until 32 weeks after infection in 1 cat. Cats in groups 1 and 2 had fever (>39.7°C) and partial anorexia by 2 weeks after infection that lasted 2-7 days. All infected cats had Bartonella- specific IgM and IgG serum antibodies and lymphocyte blastogenic responses. Histopathologic lesions were observed in multiple organs of infected cats through 8 weeks after infection. Cats were readily infected with B. henselae by intravenous inoculation, developed histopathologic lesions that apparently resolved, and developed B and T lymphocyte responses to infection.

Original languageEnglish (US)
Pages (from-to)206-216
Number of pages11
JournalJournal of Infectious Diseases
Issue number1
StatePublished - Jan 1 1997
Externally publishedYes

ASJC Scopus subject areas

  • Immunology and Allergy
  • Infectious Diseases

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