Experimental stress fractures of the tibia. Biological and mechanical aetiology in rabbits

David Burr, C. Milgrom, R. D. Boyd, W. L. Higgins, G. Robin, E. L. Radin

Research output: Contribution to journalArticle

115 Citations (Scopus)

Abstract

We have shown that stress fractures can be induced in the tibial diaphysis of an animal model by the repeated application of non-traumatic impulsive loads. The right hind limbs of 31 rabbits were loaded for three to nine weeks and changes in the bone were monitored by radiography and bone scintigraphy. The presence of stress fractures was confirmed histologically in some cases. Most animals sustained a stress fracture within six weeks and there was a positive correspondence between scintigraphic change and radiological evidence. Microscopic damage was evident at the sites of positive bone scans. The progression, location, and time of onset of stress fractures in this animal model were similar to those in clinical reports, making the model a useful one for the study of the aetiology of stress fractures.

Original languageEnglish (US)
Pages (from-to)370-375
Number of pages6
JournalJournal of Bone and Joint Surgery - Series B
Volume72
Issue number3
StatePublished - 1990
Externally publishedYes

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Stress Fractures
Tibia
Rabbits
Bone and Bones
Animal Models
Diaphyses
Radiography
Radionuclide Imaging
Extremities

ASJC Scopus subject areas

  • Orthopedics and Sports Medicine
  • Surgery

Cite this

Burr, D., Milgrom, C., Boyd, R. D., Higgins, W. L., Robin, G., & Radin, E. L. (1990). Experimental stress fractures of the tibia. Biological and mechanical aetiology in rabbits. Journal of Bone and Joint Surgery - Series B, 72(3), 370-375.

Experimental stress fractures of the tibia. Biological and mechanical aetiology in rabbits. / Burr, David; Milgrom, C.; Boyd, R. D.; Higgins, W. L.; Robin, G.; Radin, E. L.

In: Journal of Bone and Joint Surgery - Series B, Vol. 72, No. 3, 1990, p. 370-375.

Research output: Contribution to journalArticle

Burr, D, Milgrom, C, Boyd, RD, Higgins, WL, Robin, G & Radin, EL 1990, 'Experimental stress fractures of the tibia. Biological and mechanical aetiology in rabbits', Journal of Bone and Joint Surgery - Series B, vol. 72, no. 3, pp. 370-375.
Burr, David ; Milgrom, C. ; Boyd, R. D. ; Higgins, W. L. ; Robin, G. ; Radin, E. L. / Experimental stress fractures of the tibia. Biological and mechanical aetiology in rabbits. In: Journal of Bone and Joint Surgery - Series B. 1990 ; Vol. 72, No. 3. pp. 370-375.
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