Expert opinion on fecal microbiota transplantation for the treatment of Clostridioides difficile infection and beyond

Vinod Kumar, Monika Fischer

Research output: Contribution to journalReview article

Abstract

Introduction: Fecal microbiota transplantation (FMT) is a procedure involving transfer of stool from a healthy donor into the intestinal tract of a diseased recipient to restore intestinal microbial composition and functionality. FMT’s tremendous success in recurrent and refractory Clostridioides difficile infection (CDI) catalyzed gut microbiota research and opened the door to microbiome-based therapy for various gastrointestinal and other disorders. Areas covered: We used PubMed search engine to identify significant publications in the field of CDI and FMT. Here we present an overview of the current literature on FMT’s use for recurrent, non-severe, severe, and fulminant CDI and on promising future application. Expert opinion: FMT as the best tool for treatment of antibiotic-refractory CDI has gained immense popularity over the last decade. The future of gut microbiota-based therapy should include oral formulations that contain well-described ingredients in effective doses, clear mechanism of action, and excellent safety profile.

Original languageEnglish (US)
JournalExpert Opinion on Biological Therapy
DOIs
StateAccepted/In press - Jan 1 2019

Fingerprint

Expert Testimony
Refractory materials
Search engines
Infection
Anti-Bacterial Agents
Search Engine
Microbiota
Therapeutics
Chemical analysis
PubMed
Publications
Safety
Fecal Microbiota Transplantation
Research
Gastrointestinal Microbiome

Keywords

  • C. diff
  • C. diff colitis
  • Clostridioides difficile
  • colectomy
  • colonoscopy
  • dysbiosis
  • fecal microbiota transplantation
  • fulminant colitis
  • microbiota

ASJC Scopus subject areas

  • Pharmacology
  • Drug Discovery
  • Clinical Biochemistry

Cite this

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title = "Expert opinion on fecal microbiota transplantation for the treatment of Clostridioides difficile infection and beyond",
abstract = "Introduction: Fecal microbiota transplantation (FMT) is a procedure involving transfer of stool from a healthy donor into the intestinal tract of a diseased recipient to restore intestinal microbial composition and functionality. FMT’s tremendous success in recurrent and refractory Clostridioides difficile infection (CDI) catalyzed gut microbiota research and opened the door to microbiome-based therapy for various gastrointestinal and other disorders. Areas covered: We used PubMed search engine to identify significant publications in the field of CDI and FMT. Here we present an overview of the current literature on FMT’s use for recurrent, non-severe, severe, and fulminant CDI and on promising future application. Expert opinion: FMT as the best tool for treatment of antibiotic-refractory CDI has gained immense popularity over the last decade. The future of gut microbiota-based therapy should include oral formulations that contain well-described ingredients in effective doses, clear mechanism of action, and excellent safety profile.",
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AB - Introduction: Fecal microbiota transplantation (FMT) is a procedure involving transfer of stool from a healthy donor into the intestinal tract of a diseased recipient to restore intestinal microbial composition and functionality. FMT’s tremendous success in recurrent and refractory Clostridioides difficile infection (CDI) catalyzed gut microbiota research and opened the door to microbiome-based therapy for various gastrointestinal and other disorders. Areas covered: We used PubMed search engine to identify significant publications in the field of CDI and FMT. Here we present an overview of the current literature on FMT’s use for recurrent, non-severe, severe, and fulminant CDI and on promising future application. Expert opinion: FMT as the best tool for treatment of antibiotic-refractory CDI has gained immense popularity over the last decade. The future of gut microbiota-based therapy should include oral formulations that contain well-described ingredients in effective doses, clear mechanism of action, and excellent safety profile.

KW - C. diff

KW - C. diff colitis

KW - Clostridioides difficile

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KW - colonoscopy

KW - dysbiosis

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KW - fulminant colitis

KW - microbiota

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