Exploration of bacterial community classes in major human habitats

Yanjiao Zhou, Kathie A. Mihindukulasuriya, Hongyu Gao, Patricio S. La Rosa, Kristine M. Wylie, John C. Martin, Karthik Kota, William D. Shannon, Makedonka Mitreva, Erica Sodergren, George M. Weinstock

Research output: Contribution to journalArticle

43 Citations (Scopus)

Abstract

BACKGROUND: Determining bacterial abundance variation is the first step in understanding bacterial similarity between individuals. Categorization of bacterial communities into groups or community classes is the subsequent step in describing microbial distribution based on abundance patterns. Here, we present an analysis of the groupings of bacterial communities in stool, nasal, skin, vaginal and oral habitats in a healthy cohort of 236 subjects from the Human Microbiome Project.

RESULTS: We identify distinct community group patterns in the anterior nares, four skin sites, and vagina at the genus level. We also confirm three enterotypes previously identified in stools. We identify two clusters with low silhouette values in most oral sites, in which bacterial communities are more homogeneous. Subjects sharing a community class in one habitat do not necessarily share a community class in another, except in the three vaginal sites and the symmetric habitats of the left and right retroauricular creases. Demographic factors, including gender, age, and ethnicity, significantly influence community composition in several habitats. Community classes in the vagina, retroauricular crease and stool are stable over approximately 200 days.

CONCLUSION: The community composition, association of demographic factors with community classes, and demonstration of community stability deepen our understanding of the variability and dynamics of human microbiomes. This also has significant implications for experimental designs that seek microbial correlations with clinical phenotypes.

Original languageEnglish (US)
Pages (from-to)R66
JournalGenome Biology
Volume15
Issue number5
DOIs
StatePublished - 2014
Externally publishedYes

Fingerprint

bacterial communities
Ecosystem
vagina
habitat
habitats
skin (animal)
community composition
mouth
skin
demographic statistics
ethnicity
nationalities and ethnic groups
Microbiota
Vagina
experimental design
phenotype
gender
Demography
human habitat
Skin

ASJC Scopus subject areas

  • Ecology, Evolution, Behavior and Systematics
  • Genetics
  • Cell Biology

Cite this

Zhou, Y., Mihindukulasuriya, K. A., Gao, H., La Rosa, P. S., Wylie, K. M., Martin, J. C., ... Weinstock, G. M. (2014). Exploration of bacterial community classes in major human habitats. Genome Biology, 15(5), R66. https://doi.org/10.1186/gb-2014-15-5-r66

Exploration of bacterial community classes in major human habitats. / Zhou, Yanjiao; Mihindukulasuriya, Kathie A.; Gao, Hongyu; La Rosa, Patricio S.; Wylie, Kristine M.; Martin, John C.; Kota, Karthik; Shannon, William D.; Mitreva, Makedonka; Sodergren, Erica; Weinstock, George M.

In: Genome Biology, Vol. 15, No. 5, 2014, p. R66.

Research output: Contribution to journalArticle

Zhou, Y, Mihindukulasuriya, KA, Gao, H, La Rosa, PS, Wylie, KM, Martin, JC, Kota, K, Shannon, WD, Mitreva, M, Sodergren, E & Weinstock, GM 2014, 'Exploration of bacterial community classes in major human habitats', Genome Biology, vol. 15, no. 5, pp. R66. https://doi.org/10.1186/gb-2014-15-5-r66
Zhou Y, Mihindukulasuriya KA, Gao H, La Rosa PS, Wylie KM, Martin JC et al. Exploration of bacterial community classes in major human habitats. Genome Biology. 2014;15(5):R66. https://doi.org/10.1186/gb-2014-15-5-r66
Zhou, Yanjiao ; Mihindukulasuriya, Kathie A. ; Gao, Hongyu ; La Rosa, Patricio S. ; Wylie, Kristine M. ; Martin, John C. ; Kota, Karthik ; Shannon, William D. ; Mitreva, Makedonka ; Sodergren, Erica ; Weinstock, George M. / Exploration of bacterial community classes in major human habitats. In: Genome Biology. 2014 ; Vol. 15, No. 5. pp. R66.
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