Exploration of the effects of predictive testing for Huntington disease on intimate relationships

K. A. Quaid, M. K. Wesson

Research output: Contribution to journalArticle

66 Citations (Scopus)

Abstract

The focus in predictive testing for Huntington disease is beginning to shift from individuals at risk to an examination of the effects on other relatives, particularly on spouses and partners. We examine the effects of participating in a predictive testing program for 25 couples. When assessed prior to testing, spouses were significantly more depressed than their at- risk partners. After pretest counseling, 6 (24%) of the couples chose not to pursue testing. At baseline, these 6 couples had significantly higher levels of psychological distress and marital dysfunction than couples who did choose to complete testing. Of the 19 couples completing testing, 5 received an increased risk result and 14 received a decreased risk result. Prior to testing, the partners of individuals who later received an increased risk result exhibited higher levels of marital distress. At 3- and 6-month follow- ups, high-risk couples were significantly more distressed than low-risk couples. These levels of distress improved somewhat at 9 months after testing, but began to climb again at 12 months. Individuals at increased risk were significantly more distressed at all points during follow-up as compared to individuals at low risk. No significant differences were found between the partners of high- and low-risk individuals at 3, 6, 9, and 12 months after disclosure. The significance of these findings and the need to include partners in pretest counseling prior to genetic testing are discussed.

Original languageEnglish
Pages (from-to)46-51
Number of pages6
JournalAmerican Journal of Medical Genetics
Volume57
Issue number1
DOIs
StatePublished - 1995

Fingerprint

Huntington Disease
Spouses
Counseling
Disclosure
Genetic Testing
Psychology

Keywords

  • Huntington disease
  • partners
  • presymptomatic testing

ASJC Scopus subject areas

  • Genetics(clinical)

Cite this

Exploration of the effects of predictive testing for Huntington disease on intimate relationships. / Quaid, K. A.; Wesson, M. K.

In: American Journal of Medical Genetics, Vol. 57, No. 1, 1995, p. 46-51.

Research output: Contribution to journalArticle

@article{9bfb7304c79347d998cdcd6eeaf586cc,
title = "Exploration of the effects of predictive testing for Huntington disease on intimate relationships",
abstract = "The focus in predictive testing for Huntington disease is beginning to shift from individuals at risk to an examination of the effects on other relatives, particularly on spouses and partners. We examine the effects of participating in a predictive testing program for 25 couples. When assessed prior to testing, spouses were significantly more depressed than their at- risk partners. After pretest counseling, 6 (24{\%}) of the couples chose not to pursue testing. At baseline, these 6 couples had significantly higher levels of psychological distress and marital dysfunction than couples who did choose to complete testing. Of the 19 couples completing testing, 5 received an increased risk result and 14 received a decreased risk result. Prior to testing, the partners of individuals who later received an increased risk result exhibited higher levels of marital distress. At 3- and 6-month follow- ups, high-risk couples were significantly more distressed than low-risk couples. These levels of distress improved somewhat at 9 months after testing, but began to climb again at 12 months. Individuals at increased risk were significantly more distressed at all points during follow-up as compared to individuals at low risk. No significant differences were found between the partners of high- and low-risk individuals at 3, 6, 9, and 12 months after disclosure. The significance of these findings and the need to include partners in pretest counseling prior to genetic testing are discussed.",
keywords = "Huntington disease, partners, presymptomatic testing",
author = "Quaid, {K. A.} and Wesson, {M. K.}",
year = "1995",
doi = "10.1002/ajmg.1320570111",
language = "English",
volume = "57",
pages = "46--51",
journal = "American Journal of Medical Genetics, Part C: Seminars in Medical Genetics",
issn = "1552-4825",
publisher = "Wiley-Liss Inc.",
number = "1",

}

TY - JOUR

T1 - Exploration of the effects of predictive testing for Huntington disease on intimate relationships

AU - Quaid, K. A.

AU - Wesson, M. K.

PY - 1995

Y1 - 1995

N2 - The focus in predictive testing for Huntington disease is beginning to shift from individuals at risk to an examination of the effects on other relatives, particularly on spouses and partners. We examine the effects of participating in a predictive testing program for 25 couples. When assessed prior to testing, spouses were significantly more depressed than their at- risk partners. After pretest counseling, 6 (24%) of the couples chose not to pursue testing. At baseline, these 6 couples had significantly higher levels of psychological distress and marital dysfunction than couples who did choose to complete testing. Of the 19 couples completing testing, 5 received an increased risk result and 14 received a decreased risk result. Prior to testing, the partners of individuals who later received an increased risk result exhibited higher levels of marital distress. At 3- and 6-month follow- ups, high-risk couples were significantly more distressed than low-risk couples. These levels of distress improved somewhat at 9 months after testing, but began to climb again at 12 months. Individuals at increased risk were significantly more distressed at all points during follow-up as compared to individuals at low risk. No significant differences were found between the partners of high- and low-risk individuals at 3, 6, 9, and 12 months after disclosure. The significance of these findings and the need to include partners in pretest counseling prior to genetic testing are discussed.

AB - The focus in predictive testing for Huntington disease is beginning to shift from individuals at risk to an examination of the effects on other relatives, particularly on spouses and partners. We examine the effects of participating in a predictive testing program for 25 couples. When assessed prior to testing, spouses were significantly more depressed than their at- risk partners. After pretest counseling, 6 (24%) of the couples chose not to pursue testing. At baseline, these 6 couples had significantly higher levels of psychological distress and marital dysfunction than couples who did choose to complete testing. Of the 19 couples completing testing, 5 received an increased risk result and 14 received a decreased risk result. Prior to testing, the partners of individuals who later received an increased risk result exhibited higher levels of marital distress. At 3- and 6-month follow- ups, high-risk couples were significantly more distressed than low-risk couples. These levels of distress improved somewhat at 9 months after testing, but began to climb again at 12 months. Individuals at increased risk were significantly more distressed at all points during follow-up as compared to individuals at low risk. No significant differences were found between the partners of high- and low-risk individuals at 3, 6, 9, and 12 months after disclosure. The significance of these findings and the need to include partners in pretest counseling prior to genetic testing are discussed.

KW - Huntington disease

KW - partners

KW - presymptomatic testing

UR - http://www.scopus.com/inward/record.url?scp=0029007707&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=0029007707&partnerID=8YFLogxK

U2 - 10.1002/ajmg.1320570111

DO - 10.1002/ajmg.1320570111

M3 - Article

C2 - 7645597

AN - SCOPUS:0029007707

VL - 57

SP - 46

EP - 51

JO - American Journal of Medical Genetics, Part C: Seminars in Medical Genetics

JF - American Journal of Medical Genetics, Part C: Seminars in Medical Genetics

SN - 1552-4825

IS - 1

ER -