Exploring autoimmunity in the pathogenesis of abdominal aortic aneurysms

Tiffany W. Chang, Adam S A Gracon, Michael Murphy, David S. Wilkes

Research output: Contribution to journalArticle

12 Citations (Scopus)

Abstract

The abdominal aortic aneurysm (AAA) is a disease process that carries significant morbidity and mortality in the absence of early identification and treatment. While current management includes surveillance and surgical treatment of low- and high-risk aneurysms, respectively, our narrow understanding of the pathophysiology of AAAs limits our ability to more effectively manage and perhaps even prevent the occurrence of this highly morbid disease. Over the past couple of decades, there has been considerable interest in exploring the role of autoimmunity as an etiological component of AAA. This review covers the current literature pertaining to this immunological process, focusing on research that highlights the local and systemic immune components found in both human patients and murine models. A better understanding of the autoimmune mechanisms in the pathogenesis of AAAs can pave the way to novel and improved treatment strategies in this patient population.

Original languageEnglish
Pages (from-to)H719-H727
JournalAmerican Journal of Physiology - Heart and Circulatory Physiology
Volume309
Issue number5
DOIs
StatePublished - Sep 3 2015

Fingerprint

Abdominal Aortic Aneurysm
Autoimmunity
Aneurysm
Therapeutics
Morbidity
Mortality
Research
Population

Keywords

  • Abdominal aortic aneurysm
  • Antigens
  • Autoimmunity

ASJC Scopus subject areas

  • Physiology
  • Physiology (medical)
  • Cardiology and Cardiovascular Medicine

Cite this

Exploring autoimmunity in the pathogenesis of abdominal aortic aneurysms. / Chang, Tiffany W.; Gracon, Adam S A; Murphy, Michael; Wilkes, David S.

In: American Journal of Physiology - Heart and Circulatory Physiology, Vol. 309, No. 5, 03.09.2015, p. H719-H727.

Research output: Contribution to journalArticle

Chang, Tiffany W. ; Gracon, Adam S A ; Murphy, Michael ; Wilkes, David S. / Exploring autoimmunity in the pathogenesis of abdominal aortic aneurysms. In: American Journal of Physiology - Heart and Circulatory Physiology. 2015 ; Vol. 309, No. 5. pp. H719-H727.
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