Exploring the nexus of Alzheimer's disease and related dementias with cancer and cancer therapies: A convening of the Alzheimer's Association & Alzheimer's Drug Discovery Foundation

Heather M. Snyder, Tim Ahles, Stuart Calderwood, Maria C. Carrillo, Honglei Chen, Chung Chou H Chang, Suzanne Craft, Philip De Jager, Jane A. Driver, Howard Fillit, David Knopman, Michael Lotze, Mary C. Tierney, Suzana Petanceska, Andrew Saykin, Sudha Seshadri, Diana Shineman, Mary Ganguli

Research output: Contribution to journalArticle

12 Scopus citations

Abstract

Recent population studies suggest an intriguing inverse relationship between several types of cancer and neurodegenerative diseases, including Alzheimer's disease. Understanding the intersection of the underlying biology for these two distinct families of diseases with one another may offer novel approaches to identify new therapeutic approaches and possible opportunities to repurpose existing drug candidates. The Alzheimer's Association and the Alzheimer's Drug Discovery Foundation convened a one-day workshop to delve into this discussion. Workshop participants outlined research focus areas, potential collaborations, and partnerships for future action.

Original languageEnglish (US)
JournalAlzheimer's and Dementia
DOIs
StateAccepted/In press - 2016

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Keywords

  • Alzheimer's disease
  • Biological mechanisms
  • Cancer
  • Epidemiology
  • Genetics
  • Oncology
  • Repurpose therapy

ASJC Scopus subject areas

  • Epidemiology
  • Health Policy
  • Developmental Neuroscience
  • Geriatrics and Gerontology
  • Clinical Neurology
  • Cellular and Molecular Neuroscience
  • Psychiatry and Mental health

Cite this

Snyder, H. M., Ahles, T., Calderwood, S., Carrillo, M. C., Chen, H., Chang, C. C. H., Craft, S., De Jager, P., Driver, J. A., Fillit, H., Knopman, D., Lotze, M., Tierney, M. C., Petanceska, S., Saykin, A., Seshadri, S., Shineman, D., & Ganguli, M. (Accepted/In press). Exploring the nexus of Alzheimer's disease and related dementias with cancer and cancer therapies: A convening of the Alzheimer's Association & Alzheimer's Drug Discovery Foundation. Alzheimer's and Dementia. https://doi.org/10.1016/j.jalz.2016.11.002