Exposure of bladder smooth muscle cells to mechanical strain and sustained hydrostatic pressure promotes upregulation of HB-EGF and collagen type III

Karen Haberstroh, Martin Kaefer, Natacha Depaola, Rena Bizios

Research output: Contribution to journalConference article


The novel Hydrostrain system was designed to establish and maintain conditions that simulate the in vivo mechanical environment of the bladder. In this system, ovine bladder smooth muscle cells on flexible membranes were exposed simultaneously to hydrostatic pressure and mechanical strains under standard cell culture conditions for 7 hours. Results provide cellular/molecular level information relevant to bladder pathology that could have significant implications in the field of clinical urology.

Original languageEnglish (US)
Pages (from-to)S-50
JournalAnnals of Biomedical Engineering
Issue numberSUPPL. 1
StatePublished - Dec 1 2000
Event2000 Annual Fall Meeting of the Biomedical Engineering Society - Washington, WA, USA
Duration: Oct 12 2000Oct 14 2000


ASJC Scopus subject areas

  • Biomedical Engineering

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