Expression levels of protein kinase C-α in non-small-cell lung cancer

Michael Lahn, Chen Su, Shuyu Li, Marcio Chedid, Kimberly R. Hanna, Jeremy R. Graff, George E. Sandusky, Doreen Ma, Clet Niyikiza, Karen L. Sundell, William J. John, Thomas J. Giordano, David G. Beer, Blake M. Paterson, Eric Wen Su, Thomas F. Bumól

Research output: Contribution to journalArticle

35 Scopus citations

Abstract

Current treatments of non - small-cell lung cancer (NSCLC) are inadequate and new therapies are being developed that target specific cellular signaling proteins associated with tumor growth. One potential target is protein kinase C (PKC) - α, a signaling molecule with an important role in cell regulation and proliferation. The present study examines the expression levels of PKC-α in NSCLC to better understand the distribution of PKC-α in NSCLC. We analyzed tumor specimens from an independent tumor tissue bank to determine PKC-α protein and messenger RNA gene expression in NSCLC. In addition, we used publicly available gene expression array data to further understand PKC-α-associated gene expression profiles in NSCLC. We found that PKC-α is highly expressed in ≤ 20% of patients with NSCLC. We also found that PKC-α was preferentially expressed in adenocarcinoma compared with squamous cell carcinoma of the lung.

Original languageEnglish (US)
Pages (from-to)184-189
Number of pages6
JournalClinical Lung Cancer
Volume6
Issue number3
DOIs
StatePublished - Nov 2004
Externally publishedYes

Keywords

  • Adenocarcinoma
  • Aprinocarsen
  • Gene expression array
  • Squamous cell carcinoma

ASJC Scopus subject areas

  • Oncology
  • Pulmonary and Respiratory Medicine
  • Cancer Research

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  • Cite this

    Lahn, M., Su, C., Li, S., Chedid, M., Hanna, K. R., Graff, J. R., Sandusky, G. E., Ma, D., Niyikiza, C., Sundell, K. L., John, W. J., Giordano, T. J., Beer, D. G., Paterson, B. M., Su, E. W., & Bumól, T. F. (2004). Expression levels of protein kinase C-α in non-small-cell lung cancer. Clinical Lung Cancer, 6(3), 184-189. https://doi.org/10.3816/CLC.2004.n.032