Expression levels of protein kinase C-α in non-small-cell lung cancer

Michael Lahn, Chen Su, Shuyu Li, Marcio Chedid, Kimberly R. Hanna, Jeremy R. Graff, George Sandusky, Doreen Ma, Clet Niyikiza, Karen L. Sundell, William J. John, Thomas J. Giordano, David G. Beer, Blake M. Paterson, Eric Wen Su, Thomas F. Bumól

Research output: Contribution to journalArticle

34 Citations (Scopus)

Abstract

Current treatments of non - small-cell lung cancer (NSCLC) are inadequate and new therapies are being developed that target specific cellular signaling proteins associated with tumor growth. One potential target is protein kinase C (PKC) - α, a signaling molecule with an important role in cell regulation and proliferation. The present study examines the expression levels of PKC-α in NSCLC to better understand the distribution of PKC-α in NSCLC. We analyzed tumor specimens from an independent tumor tissue bank to determine PKC-α protein and messenger RNA gene expression in NSCLC. In addition, we used publicly available gene expression array data to further understand PKC-α-associated gene expression profiles in NSCLC. We found that PKC-α is highly expressed in ≤ 20% of patients with NSCLC. We also found that PKC-α was preferentially expressed in adenocarcinoma compared with squamous cell carcinoma of the lung.

Original languageEnglish (US)
Pages (from-to)184-189
Number of pages6
JournalClinical Lung Cancer
Volume6
Issue number3
StatePublished - Nov 2004
Externally publishedYes

Fingerprint

Non-Small Cell Lung Carcinoma
Protein Kinase C
Tissue Banks
Gene Expression
Neoplasms
Transcriptome
Squamous Cell Carcinoma
Proteins
Adenocarcinoma
Cell Proliferation
Lung
Messenger RNA
Therapeutics
Growth

Keywords

  • Adenocarcinoma
  • Aprinocarsen
  • Gene expression array
  • Squamous cell carcinoma

ASJC Scopus subject areas

  • Cancer Research
  • Pulmonary and Respiratory Medicine

Cite this

Lahn, M., Su, C., Li, S., Chedid, M., Hanna, K. R., Graff, J. R., ... Bumól, T. F. (2004). Expression levels of protein kinase C-α in non-small-cell lung cancer. Clinical Lung Cancer, 6(3), 184-189.

Expression levels of protein kinase C-α in non-small-cell lung cancer. / Lahn, Michael; Su, Chen; Li, Shuyu; Chedid, Marcio; Hanna, Kimberly R.; Graff, Jeremy R.; Sandusky, George; Ma, Doreen; Niyikiza, Clet; Sundell, Karen L.; John, William J.; Giordano, Thomas J.; Beer, David G.; Paterson, Blake M.; Su, Eric Wen; Bumól, Thomas F.

In: Clinical Lung Cancer, Vol. 6, No. 3, 11.2004, p. 184-189.

Research output: Contribution to journalArticle

Lahn, M, Su, C, Li, S, Chedid, M, Hanna, KR, Graff, JR, Sandusky, G, Ma, D, Niyikiza, C, Sundell, KL, John, WJ, Giordano, TJ, Beer, DG, Paterson, BM, Su, EW & Bumól, TF 2004, 'Expression levels of protein kinase C-α in non-small-cell lung cancer', Clinical Lung Cancer, vol. 6, no. 3, pp. 184-189.
Lahn M, Su C, Li S, Chedid M, Hanna KR, Graff JR et al. Expression levels of protein kinase C-α in non-small-cell lung cancer. Clinical Lung Cancer. 2004 Nov;6(3):184-189.
Lahn, Michael ; Su, Chen ; Li, Shuyu ; Chedid, Marcio ; Hanna, Kimberly R. ; Graff, Jeremy R. ; Sandusky, George ; Ma, Doreen ; Niyikiza, Clet ; Sundell, Karen L. ; John, William J. ; Giordano, Thomas J. ; Beer, David G. ; Paterson, Blake M. ; Su, Eric Wen ; Bumól, Thomas F. / Expression levels of protein kinase C-α in non-small-cell lung cancer. In: Clinical Lung Cancer. 2004 ; Vol. 6, No. 3. pp. 184-189.
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