Expression of androgen receptor and prostate-specific antigen in male breast carcinoma

Noman Kidwai, Yun Gong, Xiaoping Sun, Charuhas G. Deshpande, Anjana V. Yeldandi, M. Sambasiva Rao, Sunil Badve

Research output: Contribution to journalArticle

50 Citations (Scopus)

Abstract

Background: The androgen-regulated proteins prostate-specific antigen (PSA) and prostate-specific acid phosphatase (PSAP) are present in high concentrations in normal prostate and prostatic cancer and are considered to be tissue-specific to prostate. These markers are commonly used to diagnose metastatic prostate carcinoma at various sites including the male breast. However, expression of these two proteins in tumors arising in tissues regulated by androgens such as male breast carcinoma has not been thoroughly evaluated. Methods: In this study we analyzed the expression of PSA, PSAP and androgen receptor (AR) by immunohistochemistry in 26 cases of male breast carcinomas and correlated these with the expression of other prognostic markers. Results: AR, PSA and PSAP expression was observed in 81%, 23% and 0% of carcinomas, respectively. Combined expression of AR and PSA was observed in only four tumors. Conclusion: Although the biological significance of PSA expression in male breast carcinomas is not clear, caution should be exercised when it is used as a diagnostic marker of metastatic prostate carcinoma.

Original languageEnglish (US)
Article numberR18
JournalBreast Cancer Research
Volume6
Issue number1
DOIs
StatePublished - Nov 7 2003

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Male Breast Neoplasms
Androgen Receptors
Prostate-Specific Antigen
Prostate
Acid Phosphatase
Carcinoma
Androgens
Prostatic Neoplasms
Neoplasms
Proteins
Breast
Immunohistochemistry

Keywords

  • Androgen receptor
  • Immunohistochemistry
  • Male breast carcinoma
  • Prostate-specific antigen

ASJC Scopus subject areas

  • Oncology
  • Cancer Research

Cite this

Kidwai, N., Gong, Y., Sun, X., Deshpande, C. G., Yeldandi, A. V., Rao, M. S., & Badve, S. (2003). Expression of androgen receptor and prostate-specific antigen in male breast carcinoma. Breast Cancer Research, 6(1), [R18]. https://doi.org/10.1186/bcr733

Expression of androgen receptor and prostate-specific antigen in male breast carcinoma. / Kidwai, Noman; Gong, Yun; Sun, Xiaoping; Deshpande, Charuhas G.; Yeldandi, Anjana V.; Rao, M. Sambasiva; Badve, Sunil.

In: Breast Cancer Research, Vol. 6, No. 1, R18, 07.11.2003.

Research output: Contribution to journalArticle

Kidwai N, Gong Y, Sun X, Deshpande CG, Yeldandi AV, Rao MS et al. Expression of androgen receptor and prostate-specific antigen in male breast carcinoma. Breast Cancer Research. 2003 Nov 7;6(1). R18. https://doi.org/10.1186/bcr733
Kidwai, Noman ; Gong, Yun ; Sun, Xiaoping ; Deshpande, Charuhas G. ; Yeldandi, Anjana V. ; Rao, M. Sambasiva ; Badve, Sunil. / Expression of androgen receptor and prostate-specific antigen in male breast carcinoma. In: Breast Cancer Research. 2003 ; Vol. 6, No. 1.
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abstract = "Background: The androgen-regulated proteins prostate-specific antigen (PSA) and prostate-specific acid phosphatase (PSAP) are present in high concentrations in normal prostate and prostatic cancer and are considered to be tissue-specific to prostate. These markers are commonly used to diagnose metastatic prostate carcinoma at various sites including the male breast. However, expression of these two proteins in tumors arising in tissues regulated by androgens such as male breast carcinoma has not been thoroughly evaluated. Methods: In this study we analyzed the expression of PSA, PSAP and androgen receptor (AR) by immunohistochemistry in 26 cases of male breast carcinomas and correlated these with the expression of other prognostic markers. Results: AR, PSA and PSAP expression was observed in 81{\%}, 23{\%} and 0{\%} of carcinomas, respectively. Combined expression of AR and PSA was observed in only four tumors. Conclusion: Although the biological significance of PSA expression in male breast carcinomas is not clear, caution should be exercised when it is used as a diagnostic marker of metastatic prostate carcinoma.",
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