Expression of cyclooxygenase-2 (COX-2) in human invasive transitional cell carcinoma (TCC) of the urinary bladder

Sulma I. Mohammed, Deborah W. Knapp, David G. Bostwick, Richard Foster, Kanwar Nasir M Khan, Jaime L. Masferrer, Bryan M. Woerner, Paul W. Snyder, Alane T. Koki

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Abstract

Cyclooxygenase (COX)-inhibiting drugs have antitumor activity in canine and rodent models of urinary bladder cancer. Two isoenzymes of COX have been identified, COX-1 and COX-2. The purpose of this study was to characterize COX-1 and COX-2 expression in human invasive transitional cell carcinoma of the urinary bladder by immunohistochemistry and Western blot analysis. COX-2 was not expressed in normal urinary bladder samples but was detected in 25 of 29 (86%) invasive transitional cell carcinomas of the urinary bladder and in 6 of 8 (75%) cases of carcinoma in situ. These results indicate that COX-2 may play a role in bladder cancer in humans and support further study of COX- 2 inhibitors as potential antitumor agents in human bladder cancer.

Original languageEnglish
Pages (from-to)5647-5650
Number of pages4
JournalCancer Research
Volume59
Issue number22
StatePublished - Nov 15 1999

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Transitional Cell Carcinoma
Cyclooxygenase 2
Urinary Bladder
Urinary Bladder Neoplasms
Cyclooxygenase 1
Prostaglandin-Endoperoxide Synthases
Antineoplastic Agents
Cyclooxygenase 2 Inhibitors
Carcinoma in Situ
Isoenzymes
Canidae
Rodentia
Western Blotting
Immunohistochemistry

ASJC Scopus subject areas

  • Cancer Research
  • Oncology

Cite this

Mohammed, S. I., Knapp, D. W., Bostwick, D. G., Foster, R., Khan, K. N. M., Masferrer, J. L., ... Koki, A. T. (1999). Expression of cyclooxygenase-2 (COX-2) in human invasive transitional cell carcinoma (TCC) of the urinary bladder. Cancer Research, 59(22), 5647-5650.

Expression of cyclooxygenase-2 (COX-2) in human invasive transitional cell carcinoma (TCC) of the urinary bladder. / Mohammed, Sulma I.; Knapp, Deborah W.; Bostwick, David G.; Foster, Richard; Khan, Kanwar Nasir M; Masferrer, Jaime L.; Woerner, Bryan M.; Snyder, Paul W.; Koki, Alane T.

In: Cancer Research, Vol. 59, No. 22, 15.11.1999, p. 5647-5650.

Research output: Contribution to journalArticle

Mohammed, SI, Knapp, DW, Bostwick, DG, Foster, R, Khan, KNM, Masferrer, JL, Woerner, BM, Snyder, PW & Koki, AT 1999, 'Expression of cyclooxygenase-2 (COX-2) in human invasive transitional cell carcinoma (TCC) of the urinary bladder', Cancer Research, vol. 59, no. 22, pp. 5647-5650.
Mohammed SI, Knapp DW, Bostwick DG, Foster R, Khan KNM, Masferrer JL et al. Expression of cyclooxygenase-2 (COX-2) in human invasive transitional cell carcinoma (TCC) of the urinary bladder. Cancer Research. 1999 Nov 15;59(22):5647-5650.
Mohammed, Sulma I. ; Knapp, Deborah W. ; Bostwick, David G. ; Foster, Richard ; Khan, Kanwar Nasir M ; Masferrer, Jaime L. ; Woerner, Bryan M. ; Snyder, Paul W. ; Koki, Alane T. / Expression of cyclooxygenase-2 (COX-2) in human invasive transitional cell carcinoma (TCC) of the urinary bladder. In: Cancer Research. 1999 ; Vol. 59, No. 22. pp. 5647-5650.
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