Expression of cytokeratin 20 in mucinous bronchioloalveolar carcinoma

Rajshri N. Shah, Sunil Badve, Kashireddy Papreddy, Susanne Schindler, William B. Laskin, Anjana V. Yeldandi

Research output: Contribution to journalArticle

62 Citations (Scopus)

Abstract

Mucinous bronchioloalveolar carcinomas (BACs) can closely mimic metastatic adenocarcinoma to the lung both clinically and morphologically. Several studies have demonstrated that the differential expression of cytokeratin 7 (CK7) and cytokeratin 20 (CK20) is a valuable diagnostic tool in differentiating primary pulmonary adenocarcinomas (PPAs) (usually CK7 positive/CK20 negative) from metastatic colonic adenocarcinoma (usually CK7 negative/CK20 positive). The present study is designed to correlate the histologic subtypes of PPA with expression of 7 and 20. A total of 113 cases of bonafide PPA were selected and classified according to the 1999 World Health Organization criteria as adenocarcinoma, NOS (n = 80), nonmucinous BAC (n = 14), and mucinous BAC (n = 19). Representive sections of all the tumors were immunohistochemically analyzed for CK7 and CK20 expression. To evaluate the diagnostic utility of CK7 and CK20 expression, 6 cases of colonic adenocarcinoma metastatic to the lung were tested with the same antibodies and compared with mucinous BAC. Results were expressed in a semiquantitative fashion based on the percentage of positive tumor cells:

Original languageEnglish (US)
Pages (from-to)915-920
Number of pages6
JournalHuman Pathology
Volume33
Issue number9
DOIs
StatePublished - 2002
Externally publishedYes

Fingerprint

Keratin-20
Keratin-7
Bronchiolo-Alveolar Adenocarcinoma
Mucinous Adenocarcinoma
Adenocarcinoma
Neoplasms
Lung
Adenocarcinoma of lung
Antibodies

Keywords

  • Cytokeratin 20
  • Lung adenocarcinoma
  • Mucinous bronchioloalveolar carcinoma

ASJC Scopus subject areas

  • Pathology and Forensic Medicine

Cite this

Shah, R. N., Badve, S., Papreddy, K., Schindler, S., Laskin, W. B., & Yeldandi, A. V. (2002). Expression of cytokeratin 20 in mucinous bronchioloalveolar carcinoma. Human Pathology, 33(9), 915-920. https://doi.org/10.1053/hupa.2002.126876

Expression of cytokeratin 20 in mucinous bronchioloalveolar carcinoma. / Shah, Rajshri N.; Badve, Sunil; Papreddy, Kashireddy; Schindler, Susanne; Laskin, William B.; Yeldandi, Anjana V.

In: Human Pathology, Vol. 33, No. 9, 2002, p. 915-920.

Research output: Contribution to journalArticle

Shah, RN, Badve, S, Papreddy, K, Schindler, S, Laskin, WB & Yeldandi, AV 2002, 'Expression of cytokeratin 20 in mucinous bronchioloalveolar carcinoma', Human Pathology, vol. 33, no. 9, pp. 915-920. https://doi.org/10.1053/hupa.2002.126876
Shah, Rajshri N. ; Badve, Sunil ; Papreddy, Kashireddy ; Schindler, Susanne ; Laskin, William B. ; Yeldandi, Anjana V. / Expression of cytokeratin 20 in mucinous bronchioloalveolar carcinoma. In: Human Pathology. 2002 ; Vol. 33, No. 9. pp. 915-920.
@article{3baf0179ffbd4db0936a954e6a070538,
title = "Expression of cytokeratin 20 in mucinous bronchioloalveolar carcinoma",
abstract = "Mucinous bronchioloalveolar carcinomas (BACs) can closely mimic metastatic adenocarcinoma to the lung both clinically and morphologically. Several studies have demonstrated that the differential expression of cytokeratin 7 (CK7) and cytokeratin 20 (CK20) is a valuable diagnostic tool in differentiating primary pulmonary adenocarcinomas (PPAs) (usually CK7 positive/CK20 negative) from metastatic colonic adenocarcinoma (usually CK7 negative/CK20 positive). The present study is designed to correlate the histologic subtypes of PPA with expression of 7 and 20. A total of 113 cases of bonafide PPA were selected and classified according to the 1999 World Health Organization criteria as adenocarcinoma, NOS (n = 80), nonmucinous BAC (n = 14), and mucinous BAC (n = 19). Representive sections of all the tumors were immunohistochemically analyzed for CK7 and CK20 expression. To evaluate the diagnostic utility of CK7 and CK20 expression, 6 cases of colonic adenocarcinoma metastatic to the lung were tested with the same antibodies and compared with mucinous BAC. Results were expressed in a semiquantitative fashion based on the percentage of positive tumor cells:",
keywords = "Cytokeratin 20, Lung adenocarcinoma, Mucinous bronchioloalveolar carcinoma",
author = "Shah, {Rajshri N.} and Sunil Badve and Kashireddy Papreddy and Susanne Schindler and Laskin, {William B.} and Yeldandi, {Anjana V.}",
year = "2002",
doi = "10.1053/hupa.2002.126876",
language = "English (US)",
volume = "33",
pages = "915--920",
journal = "Human Pathology",
issn = "0046-8177",
publisher = "W.B. Saunders Ltd",
number = "9",

}

TY - JOUR

T1 - Expression of cytokeratin 20 in mucinous bronchioloalveolar carcinoma

AU - Shah, Rajshri N.

AU - Badve, Sunil

AU - Papreddy, Kashireddy

AU - Schindler, Susanne

AU - Laskin, William B.

AU - Yeldandi, Anjana V.

PY - 2002

Y1 - 2002

N2 - Mucinous bronchioloalveolar carcinomas (BACs) can closely mimic metastatic adenocarcinoma to the lung both clinically and morphologically. Several studies have demonstrated that the differential expression of cytokeratin 7 (CK7) and cytokeratin 20 (CK20) is a valuable diagnostic tool in differentiating primary pulmonary adenocarcinomas (PPAs) (usually CK7 positive/CK20 negative) from metastatic colonic adenocarcinoma (usually CK7 negative/CK20 positive). The present study is designed to correlate the histologic subtypes of PPA with expression of 7 and 20. A total of 113 cases of bonafide PPA were selected and classified according to the 1999 World Health Organization criteria as adenocarcinoma, NOS (n = 80), nonmucinous BAC (n = 14), and mucinous BAC (n = 19). Representive sections of all the tumors were immunohistochemically analyzed for CK7 and CK20 expression. To evaluate the diagnostic utility of CK7 and CK20 expression, 6 cases of colonic adenocarcinoma metastatic to the lung were tested with the same antibodies and compared with mucinous BAC. Results were expressed in a semiquantitative fashion based on the percentage of positive tumor cells:

AB - Mucinous bronchioloalveolar carcinomas (BACs) can closely mimic metastatic adenocarcinoma to the lung both clinically and morphologically. Several studies have demonstrated that the differential expression of cytokeratin 7 (CK7) and cytokeratin 20 (CK20) is a valuable diagnostic tool in differentiating primary pulmonary adenocarcinomas (PPAs) (usually CK7 positive/CK20 negative) from metastatic colonic adenocarcinoma (usually CK7 negative/CK20 positive). The present study is designed to correlate the histologic subtypes of PPA with expression of 7 and 20. A total of 113 cases of bonafide PPA were selected and classified according to the 1999 World Health Organization criteria as adenocarcinoma, NOS (n = 80), nonmucinous BAC (n = 14), and mucinous BAC (n = 19). Representive sections of all the tumors were immunohistochemically analyzed for CK7 and CK20 expression. To evaluate the diagnostic utility of CK7 and CK20 expression, 6 cases of colonic adenocarcinoma metastatic to the lung were tested with the same antibodies and compared with mucinous BAC. Results were expressed in a semiquantitative fashion based on the percentage of positive tumor cells:

KW - Cytokeratin 20

KW - Lung adenocarcinoma

KW - Mucinous bronchioloalveolar carcinoma

UR - http://www.scopus.com/inward/record.url?scp=0036741911&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=0036741911&partnerID=8YFLogxK

U2 - 10.1053/hupa.2002.126876

DO - 10.1053/hupa.2002.126876

M3 - Article

VL - 33

SP - 915

EP - 920

JO - Human Pathology

JF - Human Pathology

SN - 0046-8177

IS - 9

ER -