Expression of Hel-N1 and Hel-N2 in small-cell lung carcinoma

Peter H. King, Edward Dropcho

Research output: Contribution to journalArticle

28 Citations (Scopus)

Abstract

Hel-N1 and HuD are neuron-specific RNA-binding proteins that are antigenic targets of anti-Hu antibodies. Although expression of Hu antigens is most commonly seen in small-cell lung carcinoma, their exact identity (e.g., Hel- N1, Hel-N2, HuD, and HuC) cannot be distinguished by immunological methods. Analysis of messenger RNA expression is needed for this distinction. Here we demonstrate that Hel-N1 and Hel-N2 are expressed in small-cell lung carcinoma using reverse transcription polymerase chain reaction.

Original languageEnglish
Pages (from-to)679-681
Number of pages3
JournalAnnals of Neurology
Volume39
Issue number5
DOIs
StatePublished - May 1996

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Small Cell Lung Carcinoma
ELAV Proteins
RNA-Binding Proteins
Reverse Transcription
Anti-Idiotypic Antibodies
Neurons
Polymerase Chain Reaction
Messenger RNA

ASJC Scopus subject areas

  • Neuroscience(all)

Cite this

Expression of Hel-N1 and Hel-N2 in small-cell lung carcinoma. / King, Peter H.; Dropcho, Edward.

In: Annals of Neurology, Vol. 39, No. 5, 05.1996, p. 679-681.

Research output: Contribution to journalArticle

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