Expression of Hel-N1 and Hel-N2 in small-cell lung carcinoma

Peter H. King, Edward J. Dropcho

Research output: Contribution to journalArticle

28 Scopus citations

Abstract

Hel-N1 and HuD are neuron-specific RNA-binding proteins that are antigenic targets of anti-Hu antibodies. Although expression of Hu antigens is most commonly seen in small-cell lung carcinoma, their exact identity (e.g., Hel- N1, Hel-N2, HuD, and HuC) cannot be distinguished by immunological methods. Analysis of messenger RNA expression is needed for this distinction. Here we demonstrate that Hel-N1 and Hel-N2 are expressed in small-cell lung carcinoma using reverse transcription polymerase chain reaction.

Original languageEnglish (US)
Pages (from-to)679-681
Number of pages3
JournalAnnals of Neurology
Volume39
Issue number5
DOIs
StatePublished - May 1 1996

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ASJC Scopus subject areas

  • Neurology
  • Clinical Neurology

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