Hel-N1 and HuD are neuron-specific RNA-binding proteins that are antigenic targets of anti-Hu antibodies. Although expression of Hu antigens is most commonly seen in small-cell lung carcinoma, their exact identity (e.g., Hel- N1, Hel-N2, HuD, and HuC) cannot be distinguished by immunological methods. Analysis of messenger RNA expression is needed for this distinction. Here we demonstrate that Hel-N1 and Hel-N2 are expressed in small-cell lung carcinoma using reverse transcription polymerase chain reaction.
ASJC Scopus subject areas
- Clinical Neurology