Expression of hydra head activator in newt tissues and effects on limb regeneration

E. J. Fuentes, A. L. Mescher, R. Ekman, P. A. Tsonis

Research output: Contribution to journalArticle


In this study, the presence of the hydra head activator (HHA) neuropeptide and its influence on regenerating newt limbs (Notophthalmus viridescens) was investigated. Immunohistological analysis has localized the HHA neuropeptide in the adult newt brain, eye, intestine, and regenerating blastema. Experiments in which 9 day limb regenerates were denervated and subsequently implanted with HHA-soaked beads suggest a slight progression of blastema growth compared to denervated controls.

Original languageEnglish (US)
Pages (from-to)59-63
Number of pages5
JournalIn Vivo
Issue number1
StatePublished - Jan 1 1993



  • hydra head activator
  • limb generation
  • newt

ASJC Scopus subject areas

  • Biochemistry, Genetics and Molecular Biology(all)
  • Pharmacology

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