Expression of NFκB, ICAM1, and VCAM1 in rheumatic heart disease with atrial fibrillation

Li Ping Chen, Hui Liu, Yuan Huang, Xiang yan Zhang, Riley E. Alexander, Liang Cheng

Research output: Contribution to journalArticle

3 Scopus citations

Abstract

OBJECTIVE: To examine the expression of nuclear factor kappaB (NFκB), intercellular adhesion molecule 1 (ICAM1), and vascular cell adhesion molecule 1 (VCAM1) levels in rheumatic heart disease patients who suffer from atrial fibrillation and those who do not. STUDY DESIGN: Twenty-six patients with rheumatic heart disease were enrolled. Ten patients had no history of atrial fibrillation and 16 had atrial fibrillation. Atrial tissue was obtained from the right atrial appendage during heart surgery. The expression levels of NFκB, ICAM1, and VCAM1 were examined with immunohistochemical staining. RESULTS: Myocardial inflammation and fibrosis were both increased in patients with atrial fibrillation. The levels of NFκB, ICAM1, and VCAM1 were significantly elevated in patients with atrial fibrillation as compared with the control group (all p<0.05). CONCLUSION: Overexpression of NFκB, ICAM1, and VCAM1 may be involved in the development and maintenance of atrial fibrillation in patients with rheumatic heart disease. (Anal Quant Cytopathol Histopathol 2013;35:249-252).

Original languageEnglish (US)
Pages (from-to)249-252
Number of pages4
JournalAnalytical and Quantitative Cytology and Histology
Volume35
Issue number5
StatePublished - Oct 1 2013

Keywords

  • Atrial fibrillation
  • Intercellular adhesion molecule-1
  • Nuclear factor-kappa B
  • Rheumatic heart disease
  • Vascular cell adhesion molecule-1

ASJC Scopus subject areas

  • Anatomy
  • Histology
  • Medicine(all)

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