Expression of NF-κB and ERK following heavy ion irradiation

Anirban Kumar Mitra, Asiti Sarma, Malini Krishna, Naresh Chandra Verma

Research output: Contribution to journalArticle

7 Scopus citations

Abstract

Heavy ion irradiation of cells is known to increase cytotoxic, mutagenic, and carcinogenic effects. the increased biological effectiveness of these ions is as yet unexplained, except for the fact that, unlike γ-radiation, they result in clustered damage. It is likely that the increased biological effectiveness is a consequence of altered signaling pattern, which in turn maybe due to the difference in the nature of damage produced. Gamma irradiation has been known to activate both pro- and anti-apoptotic signaling pathways. Nuclear factor-κB (NF-κB) and extracellular signal regulated kinase (ERK) contribute to the survival of the irradiated cell. Moreover, NF-κB acts as a redox sensor. In the present study, we examined NF-κB and ERK as antiapoptotic factors that could lead to the inhibition of apoptosis and, consequently, to increased mutagenicity. Both these signaling factors show a fluctuation in their levels with time.

Original languageEnglish (US)
Article numberJEP2301-053-060(406)
Pages (from-to)53-59
Number of pages7
JournalJournal of Environmental Pathology, Toxicology and Oncology
Volume23
Issue number1
DOIs
StatePublished - Dec 1 2004

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Keywords

  • ERK
  • Heavy ion irradiation
  • NF-κB
  • V79 cells

ASJC Scopus subject areas

  • Pathology and Forensic Medicine
  • Toxicology
  • Health, Toxicology and Mutagenesis

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