Expression of the neural cell adhesion molecule CD56 is not associated with P-glycoprotein overexpression in core-binding factor acute myeloid leukemia

Attaya Suvannasankha, Hans Minderman, Kieran L. O'Loughlin, Sheila N J Sait, Carleton C. Stewart, William R. Greco, Maria R. Baer

Research output: Contribution to journalArticle

5 Citations (Scopus)

Abstract

Acute myeloid leukemia (AML) with rearrangement of the core-binding factor (CBF) α or β subunit gene has a favorable prognosis, but CD56 expression in CBFα-AML is associated with short disease-free survival. A proposed mechanism is overexpression of the multidrug resistance (MDR) protein P-glycoprotein (Pgp). CD56 expression, Pgp expression and function, and expression of the additional MDR proteins multidrug resistance protein-1 (MRP-1), lung resistance protein (LRP) and breast cancer resistance protein (BCRP) were studied in pretreatment blasts from 25 CBF-AML patients. CD56 expression was frequent in CBFα but rare in CBFβ, and Pgp expression and function were frequent in both subtypes. CD56 expression did not correlate with Pgp expression or function, nor with expression of the other MDR proteins. Treatment failure associated with CD56 expression in CBFα-AML is not likely attributable to Pgp.

Original languageEnglish (US)
Pages (from-to)449-455
Number of pages7
JournalLeukemia Research
Volume28
Issue number5
DOIs
StatePublished - May 2004
Externally publishedYes

Fingerprint

Core Binding Factors
Neural Cell Adhesion Molecules
P-Glycoprotein
Acute Myeloid Leukemia
P-Glycoproteins
Treatment Failure
Disease-Free Survival
Breast Neoplasms

Keywords

  • ABC
  • Acute myeloid leukemia
  • AML
  • ARA
  • ATP-binding cassette
  • CBF
  • Complete remission
  • Core binding factor
  • CR
  • DFS
  • Disease free survival
  • MDR
  • MRP-1
  • Multidrug resistance
  • Multidrug resistance protein-1
  • Natural killer
  • NK
  • P-glycoprotein
  • Pgp

ASJC Scopus subject areas

  • Cancer Research
  • Hematology
  • Oncology

Cite this

Expression of the neural cell adhesion molecule CD56 is not associated with P-glycoprotein overexpression in core-binding factor acute myeloid leukemia. / Suvannasankha, Attaya; Minderman, Hans; O'Loughlin, Kieran L.; Sait, Sheila N J; Stewart, Carleton C.; Greco, William R.; Baer, Maria R.

In: Leukemia Research, Vol. 28, No. 5, 05.2004, p. 449-455.

Research output: Contribution to journalArticle

Suvannasankha, Attaya ; Minderman, Hans ; O'Loughlin, Kieran L. ; Sait, Sheila N J ; Stewart, Carleton C. ; Greco, William R. ; Baer, Maria R. / Expression of the neural cell adhesion molecule CD56 is not associated with P-glycoprotein overexpression in core-binding factor acute myeloid leukemia. In: Leukemia Research. 2004 ; Vol. 28, No. 5. pp. 449-455.
@article{38d1fa0de7fb4798a2117ef1e49fb4ee,
title = "Expression of the neural cell adhesion molecule CD56 is not associated with P-glycoprotein overexpression in core-binding factor acute myeloid leukemia",
abstract = "Acute myeloid leukemia (AML) with rearrangement of the core-binding factor (CBF) α or β subunit gene has a favorable prognosis, but CD56 expression in CBFα-AML is associated with short disease-free survival. A proposed mechanism is overexpression of the multidrug resistance (MDR) protein P-glycoprotein (Pgp). CD56 expression, Pgp expression and function, and expression of the additional MDR proteins multidrug resistance protein-1 (MRP-1), lung resistance protein (LRP) and breast cancer resistance protein (BCRP) were studied in pretreatment blasts from 25 CBF-AML patients. CD56 expression was frequent in CBFα but rare in CBFβ, and Pgp expression and function were frequent in both subtypes. CD56 expression did not correlate with Pgp expression or function, nor with expression of the other MDR proteins. Treatment failure associated with CD56 expression in CBFα-AML is not likely attributable to Pgp.",
keywords = "ABC, Acute myeloid leukemia, AML, ARA, ATP-binding cassette, CBF, Complete remission, Core binding factor, CR, DFS, Disease free survival, MDR, MRP-1, Multidrug resistance, Multidrug resistance protein-1, Natural killer, NK, P-glycoprotein, Pgp",
author = "Attaya Suvannasankha and Hans Minderman and O'Loughlin, {Kieran L.} and Sait, {Sheila N J} and Stewart, {Carleton C.} and Greco, {William R.} and Baer, {Maria R.}",
year = "2004",
month = "5",
doi = "10.1016/j.leukres.2003.09.003",
language = "English (US)",
volume = "28",
pages = "449--455",
journal = "Leukemia Research",
issn = "0145-2126",
publisher = "Elsevier Limited",
number = "5",

}

TY - JOUR

T1 - Expression of the neural cell adhesion molecule CD56 is not associated with P-glycoprotein overexpression in core-binding factor acute myeloid leukemia

AU - Suvannasankha, Attaya

AU - Minderman, Hans

AU - O'Loughlin, Kieran L.

AU - Sait, Sheila N J

AU - Stewart, Carleton C.

AU - Greco, William R.

AU - Baer, Maria R.

PY - 2004/5

Y1 - 2004/5

N2 - Acute myeloid leukemia (AML) with rearrangement of the core-binding factor (CBF) α or β subunit gene has a favorable prognosis, but CD56 expression in CBFα-AML is associated with short disease-free survival. A proposed mechanism is overexpression of the multidrug resistance (MDR) protein P-glycoprotein (Pgp). CD56 expression, Pgp expression and function, and expression of the additional MDR proteins multidrug resistance protein-1 (MRP-1), lung resistance protein (LRP) and breast cancer resistance protein (BCRP) were studied in pretreatment blasts from 25 CBF-AML patients. CD56 expression was frequent in CBFα but rare in CBFβ, and Pgp expression and function were frequent in both subtypes. CD56 expression did not correlate with Pgp expression or function, nor with expression of the other MDR proteins. Treatment failure associated with CD56 expression in CBFα-AML is not likely attributable to Pgp.

AB - Acute myeloid leukemia (AML) with rearrangement of the core-binding factor (CBF) α or β subunit gene has a favorable prognosis, but CD56 expression in CBFα-AML is associated with short disease-free survival. A proposed mechanism is overexpression of the multidrug resistance (MDR) protein P-glycoprotein (Pgp). CD56 expression, Pgp expression and function, and expression of the additional MDR proteins multidrug resistance protein-1 (MRP-1), lung resistance protein (LRP) and breast cancer resistance protein (BCRP) were studied in pretreatment blasts from 25 CBF-AML patients. CD56 expression was frequent in CBFα but rare in CBFβ, and Pgp expression and function were frequent in both subtypes. CD56 expression did not correlate with Pgp expression or function, nor with expression of the other MDR proteins. Treatment failure associated with CD56 expression in CBFα-AML is not likely attributable to Pgp.

KW - ABC

KW - Acute myeloid leukemia

KW - AML

KW - ARA

KW - ATP-binding cassette

KW - CBF

KW - Complete remission

KW - Core binding factor

KW - CR

KW - DFS

KW - Disease free survival

KW - MDR

KW - MRP-1

KW - Multidrug resistance

KW - Multidrug resistance protein-1

KW - Natural killer

KW - NK

KW - P-glycoprotein

KW - Pgp

UR - http://www.scopus.com/inward/record.url?scp=1842455186&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=1842455186&partnerID=8YFLogxK

U2 - 10.1016/j.leukres.2003.09.003

DO - 10.1016/j.leukres.2003.09.003

M3 - Article

C2 - 15068897

AN - SCOPUS:1842455186

VL - 28

SP - 449

EP - 455

JO - Leukemia Research

JF - Leukemia Research

SN - 0145-2126

IS - 5

ER -