Abstract
Acute myeloid leukemia (AML) with rearrangement of the core-binding factor (CBF) α or β subunit gene has a favorable prognosis, but CD56 expression in CBFα-AML is associated with short disease-free survival. A proposed mechanism is overexpression of the multidrug resistance (MDR) protein P-glycoprotein (Pgp). CD56 expression, Pgp expression and function, and expression of the additional MDR proteins multidrug resistance protein-1 (MRP-1), lung resistance protein (LRP) and breast cancer resistance protein (BCRP) were studied in pretreatment blasts from 25 CBF-AML patients. CD56 expression was frequent in CBFα but rare in CBFβ, and Pgp expression and function were frequent in both subtypes. CD56 expression did not correlate with Pgp expression or function, nor with expression of the other MDR proteins. Treatment failure associated with CD56 expression in CBFα-AML is not likely attributable to Pgp.
| Original language | English (US) |
|---|---|
| Pages (from-to) | 449-455 |
| Number of pages | 7 |
| Journal | Leukemia Research |
| Volume | 28 |
| Issue number | 5 |
| DOIs | |
| State | Published - May 1 2004 |
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Keywords
- ABC
- AML
- ARA
- ATP-binding cassette
- Acute myeloid leukemia
- CBF
- CR
- Complete remission
- Core binding factor
- DFS
- Disease free survival
- MDR
- MRP-1
- Multidrug resistance
- Multidrug resistance protein-1
- NK
- Natural killer
- P-glycoprotein
- Pgp
ASJC Scopus subject areas
- Hematology
- Oncology
- Cancer Research
Cite this
Expression of the neural cell adhesion molecule CD56 is not associated with P-glycoprotein overexpression in core-binding factor acute myeloid leukemia. / Suvannasankha, Attaya; Minderman, Hans; O'Loughlin, Kieran L.; Sait, Sheila N.J.; Stewart, Carleton C.; Greco, William R.; Baer, Maria R.
In: Leukemia Research, Vol. 28, No. 5, 01.05.2004, p. 449-455.Research output: Contribution to journal › Article
}
TY - JOUR
T1 - Expression of the neural cell adhesion molecule CD56 is not associated with P-glycoprotein overexpression in core-binding factor acute myeloid leukemia
AU - Suvannasankha, Attaya
AU - Minderman, Hans
AU - O'Loughlin, Kieran L.
AU - Sait, Sheila N.J.
AU - Stewart, Carleton C.
AU - Greco, William R.
AU - Baer, Maria R.
PY - 2004/5/1
Y1 - 2004/5/1
N2 - Acute myeloid leukemia (AML) with rearrangement of the core-binding factor (CBF) α or β subunit gene has a favorable prognosis, but CD56 expression in CBFα-AML is associated with short disease-free survival. A proposed mechanism is overexpression of the multidrug resistance (MDR) protein P-glycoprotein (Pgp). CD56 expression, Pgp expression and function, and expression of the additional MDR proteins multidrug resistance protein-1 (MRP-1), lung resistance protein (LRP) and breast cancer resistance protein (BCRP) were studied in pretreatment blasts from 25 CBF-AML patients. CD56 expression was frequent in CBFα but rare in CBFβ, and Pgp expression and function were frequent in both subtypes. CD56 expression did not correlate with Pgp expression or function, nor with expression of the other MDR proteins. Treatment failure associated with CD56 expression in CBFα-AML is not likely attributable to Pgp.
AB - Acute myeloid leukemia (AML) with rearrangement of the core-binding factor (CBF) α or β subunit gene has a favorable prognosis, but CD56 expression in CBFα-AML is associated with short disease-free survival. A proposed mechanism is overexpression of the multidrug resistance (MDR) protein P-glycoprotein (Pgp). CD56 expression, Pgp expression and function, and expression of the additional MDR proteins multidrug resistance protein-1 (MRP-1), lung resistance protein (LRP) and breast cancer resistance protein (BCRP) were studied in pretreatment blasts from 25 CBF-AML patients. CD56 expression was frequent in CBFα but rare in CBFβ, and Pgp expression and function were frequent in both subtypes. CD56 expression did not correlate with Pgp expression or function, nor with expression of the other MDR proteins. Treatment failure associated with CD56 expression in CBFα-AML is not likely attributable to Pgp.
KW - ABC
KW - AML
KW - ARA
KW - ATP-binding cassette
KW - Acute myeloid leukemia
KW - CBF
KW - CR
KW - Complete remission
KW - Core binding factor
KW - DFS
KW - Disease free survival
KW - MDR
KW - MRP-1
KW - Multidrug resistance
KW - Multidrug resistance protein-1
KW - NK
KW - Natural killer
KW - P-glycoprotein
KW - Pgp
UR - http://www.scopus.com/inward/record.url?scp=1842455186&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=1842455186&partnerID=8YFLogxK
U2 - 10.1016/j.leukres.2003.09.003
DO - 10.1016/j.leukres.2003.09.003
M3 - Article
C2 - 15068897
AN - SCOPUS:1842455186
VL - 28
SP - 449
EP - 455
JO - Leukemia Research
JF - Leukemia Research
SN - 0145-2126
IS - 5
ER -