Expression of the neural cell adhesion molecule CD56 is not associated with P-glycoprotein overexpression in core-binding factor acute myeloid leukemia

Attaya Suvannasankha; Hans Minderman; Kieran L. O'Loughlin; Sheila N.J. Sait; Carleton C. Stewart; William R. Greco; Maria R. Baer

doi:10.1016/j.leukres.2003.09.003

Expression of the neural cell adhesion molecule CD56 is not associated with P-glycoprotein overexpression in core-binding factor acute myeloid leukemia

Attaya Suvannasankha, Hans Minderman, Kieran L. O'Loughlin, Sheila N.J. Sait, Carleton C. Stewart, William R. Greco, Maria R. Baer

Hematology/Oncology

Research output: Contribution to journal › Article

5 Scopus citations

Abstract

Acute myeloid leukemia (AML) with rearrangement of the core-binding factor (CBF) α or β subunit gene has a favorable prognosis, but CD56 expression in CBFα-AML is associated with short disease-free survival. A proposed mechanism is overexpression of the multidrug resistance (MDR) protein P-glycoprotein (Pgp). CD56 expression, Pgp expression and function, and expression of the additional MDR proteins multidrug resistance protein-1 (MRP-1), lung resistance protein (LRP) and breast cancer resistance protein (BCRP) were studied in pretreatment blasts from 25 CBF-AML patients. CD56 expression was frequent in CBFα but rare in CBFβ, and Pgp expression and function were frequent in both subtypes. CD56 expression did not correlate with Pgp expression or function, nor with expression of the other MDR proteins. Treatment failure associated with CD56 expression in CBFα-AML is not likely attributable to Pgp.

Original language	English (US)
Pages (from-to)	449-455
Number of pages	7
Journal	Leukemia Research
Volume	28
Issue number	5
DOIs	https://doi.org/10.1016/j.leukres.2003.09.003
State	Published - May 2004

Keywords

ABC
AML
ARA
ATP-binding cassette
Acute myeloid leukemia
CBF
CR
Complete remission
Core binding factor
DFS
Disease free survival
MDR
MRP-1
Multidrug resistance
Multidrug resistance protein-1
NK
Natural killer
P-glycoprotein
Pgp

ASJC Scopus subject areas

Hematology
Oncology
Cancer Research

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Suvannasankha, A., Minderman, H., O'Loughlin, K. L., Sait, S. N. J., Stewart, C. C., Greco, W. R., & Baer, M. R. (2004). Expression of the neural cell adhesion molecule CD56 is not associated with P-glycoprotein overexpression in core-binding factor acute myeloid leukemia. Leukemia Research, 28(5), 449-455. https://doi.org/10.1016/j.leukres.2003.09.003

Expression of the neural cell adhesion molecule CD56 is not associated with P-glycoprotein overexpression in core-binding factor acute myeloid leukemia. / Suvannasankha, Attaya; Minderman, Hans; O'Loughlin, Kieran L.; Sait, Sheila N.J.; Stewart, Carleton C.; Greco, William R.; Baer, Maria R.

In: Leukemia Research, Vol. 28, No. 5, 05.2004, p. 449-455.

Research output: Contribution to journal › Article

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title = "Expression of the neural cell adhesion molecule CD56 is not associated with P-glycoprotein overexpression in core-binding factor acute myeloid leukemia",

abstract = "Acute myeloid leukemia (AML) with rearrangement of the core-binding factor (CBF) α or β subunit gene has a favorable prognosis, but CD56 expression in CBFα-AML is associated with short disease-free survival. A proposed mechanism is overexpression of the multidrug resistance (MDR) protein P-glycoprotein (Pgp). CD56 expression, Pgp expression and function, and expression of the additional MDR proteins multidrug resistance protein-1 (MRP-1), lung resistance protein (LRP) and breast cancer resistance protein (BCRP) were studied in pretreatment blasts from 25 CBF-AML patients. CD56 expression was frequent in CBFα but rare in CBFβ, and Pgp expression and function were frequent in both subtypes. CD56 expression did not correlate with Pgp expression or function, nor with expression of the other MDR proteins. Treatment failure associated with CD56 expression in CBFα-AML is not likely attributable to Pgp.",

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author = "Attaya Suvannasankha and Hans Minderman and O'Loughlin, {Kieran L.} and Sait, {Sheila N.J.} and Stewart, {Carleton C.} and Greco, {William R.} and Baer, {Maria R.}",

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AU - Sait, Sheila N.J.

AU - Stewart, Carleton C.

AU - Greco, William R.

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AB - Acute myeloid leukemia (AML) with rearrangement of the core-binding factor (CBF) α or β subunit gene has a favorable prognosis, but CD56 expression in CBFα-AML is associated with short disease-free survival. A proposed mechanism is overexpression of the multidrug resistance (MDR) protein P-glycoprotein (Pgp). CD56 expression, Pgp expression and function, and expression of the additional MDR proteins multidrug resistance protein-1 (MRP-1), lung resistance protein (LRP) and breast cancer resistance protein (BCRP) were studied in pretreatment blasts from 25 CBF-AML patients. CD56 expression was frequent in CBFα but rare in CBFβ, and Pgp expression and function were frequent in both subtypes. CD56 expression did not correlate with Pgp expression or function, nor with expression of the other MDR proteins. Treatment failure associated with CD56 expression in CBFα-AML is not likely attributable to Pgp.

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