Expression of the transcriptional activator tax protein of human T‐cell leukemia virus type I increases the radiosensitivity of a mouse fibroblast cell line to ionizing radiation

Maria Alessandra Santucci, Christie A. Holland, Pervin Anklesaria, Indra Das, T. J. Fitzgerald, Michael G. McKenna, Mary Ann Sakakeeny, Joel S. Greenberger

Research output: Contribution to journalArticle

2 Citations (Scopus)

Abstract

Human T‐cell leukemia virus type I (HTLV‐1) is the etiologic agent for adult T‐cell leukemia (ATL). Among the X region products of HTLV‐1, the p42 kDa protein Tax was identified, as responsible for cell immortalization and transformation. However, the observations that only a low percentage of individuals infected with HTLV‐1 eventually progress to leukemia and that leukemic transformation of HTLV‐1‐infected cells is associated with aberrant karyotype suggest that additional genetic events are required for HTLV‐1‐induced malignant transformation. Results of our study demonstrate that expression of the Tax protein of HTLV‐1 increased the radiosensitivity of a mouse fibroblast cell line. These data are consistent with a previous report indicating a negative regulatory control by Tax on DNA repair. Unrepaired DNA damage and karyotypic instability could represent a common factor in both the initiation and progression of HTLV‐1‐related diseases. © 1993 Wiley‐Liss, Inc.

Original languageEnglish (US)
Pages (from-to)131-136
Number of pages6
JournalRadiation Oncology Investigations
Volume1
Issue number3
DOIs
StatePublished - 1993

Fingerprint

tax Gene Products
leukemias
Radiation Tolerance
fibroblasts
viruses
radiation tolerance
Ionizing Radiation
cultured cells
ionizing radiation
mice
Leukemia
Fibroblasts
Viruses
proteins
Cell Line
deoxyribonucleic acid
cells
Karyotype
progressions
DNA Repair

Keywords

  • HTLV‐1
  • ionizing irradiation
  • radiation repair
  • Tax
  • tumor progression

ASJC Scopus subject areas

  • Radiation
  • Radiological and Ultrasound Technology
  • Oncology
  • Radiology Nuclear Medicine and imaging

Cite this

Expression of the transcriptional activator tax protein of human T‐cell leukemia virus type I increases the radiosensitivity of a mouse fibroblast cell line to ionizing radiation. / Santucci, Maria Alessandra; Holland, Christie A.; Anklesaria, Pervin; Das, Indra; Fitzgerald, T. J.; McKenna, Michael G.; Sakakeeny, Mary Ann; Greenberger, Joel S.

In: Radiation Oncology Investigations, Vol. 1, No. 3, 1993, p. 131-136.

Research output: Contribution to journalArticle

Santucci, Maria Alessandra ; Holland, Christie A. ; Anklesaria, Pervin ; Das, Indra ; Fitzgerald, T. J. ; McKenna, Michael G. ; Sakakeeny, Mary Ann ; Greenberger, Joel S. / Expression of the transcriptional activator tax protein of human T‐cell leukemia virus type I increases the radiosensitivity of a mouse fibroblast cell line to ionizing radiation. In: Radiation Oncology Investigations. 1993 ; Vol. 1, No. 3. pp. 131-136.
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AU - Fitzgerald, T. J.

AU - McKenna, Michael G.

AU - Sakakeeny, Mary Ann

AU - Greenberger, Joel S.

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