Extending the reach of public health genomics

What should be the agenda for public health in an era of genome-based and "personalized" medicine?

Wylie Burke, Hilary Burton, Alison E. Hall, Mohamed Karmali, Muin J. Khoury, Bartha Knoppers, Eric M. Meslin, Fiona Stanley, Caroline F. Wright, Ronald L. Zimmern

Research output: Contribution to journalArticle

62 Citations (Scopus)

Abstract

The decade following the completion of the Human Genome Project has been marked by divergent claims about the utility of genomics for improving population health. On the one hand, genomics is viewed as the harbinger of a brave new world in which novel treatments rectify known causes of disease. On the other hand, genomics may have little practical relevance to the principal causes or remedies of diseases which are predominantly social or environmental in origin, particularly in low- and middle-income countries. Those supportive of a role for public health genomics argue that increasing knowledge of genomics and molecular pathology could unlock effective diagnostic techniques and treatments, and better target public health interventions. To resolve some of these tensions, an international multidisciplinary meeting was held in May 2010 in Ickworth, United Kingdom, with the aim of setting an agenda for the development of public health in an era of genome-based and " personalized" medicine. A number of key themes emerged, suggesting a need to reconfigure both the focus for existing genomic research and the stage at which funding is targeted, so that priority is given to areas of greatest potential health impact and that translation from basic science to implementation is given greater emphasis. To support these developments, there should be an immediate, sustained and systematic effort to provide an evidence base. These deliberations formed the basis for six key recommendations, which could guide the practice of public health in an era of genomics and personalized medicine.

Original languageEnglish
Pages (from-to)785-791
Number of pages7
JournalGenetics in Medicine
Volume12
Issue number12
DOIs
StatePublished - Dec 2010

Fingerprint

Precision Medicine
Genomics
Public Health
Genome
Public Health Practice
Human Genome Project
Metagenomics
Molecular Pathology
Health
Therapeutics
Research

Keywords

  • ethics
  • genomics
  • global health
  • public health
  • research priorities
  • translation

ASJC Scopus subject areas

  • Genetics(clinical)

Cite this

Extending the reach of public health genomics : What should be the agenda for public health in an era of genome-based and "personalized" medicine? / Burke, Wylie; Burton, Hilary; Hall, Alison E.; Karmali, Mohamed; Khoury, Muin J.; Knoppers, Bartha; Meslin, Eric M.; Stanley, Fiona; Wright, Caroline F.; Zimmern, Ronald L.

In: Genetics in Medicine, Vol. 12, No. 12, 12.2010, p. 785-791.

Research output: Contribution to journalArticle

Burke, W, Burton, H, Hall, AE, Karmali, M, Khoury, MJ, Knoppers, B, Meslin, EM, Stanley, F, Wright, CF & Zimmern, RL 2010, 'Extending the reach of public health genomics: What should be the agenda for public health in an era of genome-based and "personalized" medicine?', Genetics in Medicine, vol. 12, no. 12, pp. 785-791. https://doi.org/10.1097/GIM.0b013e3182011222
Burke, Wylie ; Burton, Hilary ; Hall, Alison E. ; Karmali, Mohamed ; Khoury, Muin J. ; Knoppers, Bartha ; Meslin, Eric M. ; Stanley, Fiona ; Wright, Caroline F. ; Zimmern, Ronald L. / Extending the reach of public health genomics : What should be the agenda for public health in an era of genome-based and "personalized" medicine?. In: Genetics in Medicine. 2010 ; Vol. 12, No. 12. pp. 785-791.
@article{1308e4e18bc44021869c9aba16ab9be8,
title = "Extending the reach of public health genomics: What should be the agenda for public health in an era of genome-based and {"}personalized{"} medicine?",
abstract = "The decade following the completion of the Human Genome Project has been marked by divergent claims about the utility of genomics for improving population health. On the one hand, genomics is viewed as the harbinger of a brave new world in which novel treatments rectify known causes of disease. On the other hand, genomics may have little practical relevance to the principal causes or remedies of diseases which are predominantly social or environmental in origin, particularly in low- and middle-income countries. Those supportive of a role for public health genomics argue that increasing knowledge of genomics and molecular pathology could unlock effective diagnostic techniques and treatments, and better target public health interventions. To resolve some of these tensions, an international multidisciplinary meeting was held in May 2010 in Ickworth, United Kingdom, with the aim of setting an agenda for the development of public health in an era of genome-based and {"} personalized{"} medicine. A number of key themes emerged, suggesting a need to reconfigure both the focus for existing genomic research and the stage at which funding is targeted, so that priority is given to areas of greatest potential health impact and that translation from basic science to implementation is given greater emphasis. To support these developments, there should be an immediate, sustained and systematic effort to provide an evidence base. These deliberations formed the basis for six key recommendations, which could guide the practice of public health in an era of genomics and personalized medicine.",
keywords = "ethics, genomics, global health, public health, research priorities, translation",
author = "Wylie Burke and Hilary Burton and Hall, {Alison E.} and Mohamed Karmali and Khoury, {Muin J.} and Bartha Knoppers and Meslin, {Eric M.} and Fiona Stanley and Wright, {Caroline F.} and Zimmern, {Ronald L.}",
year = "2010",
month = "12",
doi = "10.1097/GIM.0b013e3182011222",
language = "English",
volume = "12",
pages = "785--791",
journal = "Genetics in Medicine",
issn = "1098-3600",
publisher = "Lippincott Williams and Wilkins",
number = "12",

}

TY - JOUR

T1 - Extending the reach of public health genomics

T2 - What should be the agenda for public health in an era of genome-based and "personalized" medicine?

AU - Burke, Wylie

AU - Burton, Hilary

AU - Hall, Alison E.

AU - Karmali, Mohamed

AU - Khoury, Muin J.

AU - Knoppers, Bartha

AU - Meslin, Eric M.

AU - Stanley, Fiona

AU - Wright, Caroline F.

AU - Zimmern, Ronald L.

PY - 2010/12

Y1 - 2010/12

N2 - The decade following the completion of the Human Genome Project has been marked by divergent claims about the utility of genomics for improving population health. On the one hand, genomics is viewed as the harbinger of a brave new world in which novel treatments rectify known causes of disease. On the other hand, genomics may have little practical relevance to the principal causes or remedies of diseases which are predominantly social or environmental in origin, particularly in low- and middle-income countries. Those supportive of a role for public health genomics argue that increasing knowledge of genomics and molecular pathology could unlock effective diagnostic techniques and treatments, and better target public health interventions. To resolve some of these tensions, an international multidisciplinary meeting was held in May 2010 in Ickworth, United Kingdom, with the aim of setting an agenda for the development of public health in an era of genome-based and " personalized" medicine. A number of key themes emerged, suggesting a need to reconfigure both the focus for existing genomic research and the stage at which funding is targeted, so that priority is given to areas of greatest potential health impact and that translation from basic science to implementation is given greater emphasis. To support these developments, there should be an immediate, sustained and systematic effort to provide an evidence base. These deliberations formed the basis for six key recommendations, which could guide the practice of public health in an era of genomics and personalized medicine.

AB - The decade following the completion of the Human Genome Project has been marked by divergent claims about the utility of genomics for improving population health. On the one hand, genomics is viewed as the harbinger of a brave new world in which novel treatments rectify known causes of disease. On the other hand, genomics may have little practical relevance to the principal causes or remedies of diseases which are predominantly social or environmental in origin, particularly in low- and middle-income countries. Those supportive of a role for public health genomics argue that increasing knowledge of genomics and molecular pathology could unlock effective diagnostic techniques and treatments, and better target public health interventions. To resolve some of these tensions, an international multidisciplinary meeting was held in May 2010 in Ickworth, United Kingdom, with the aim of setting an agenda for the development of public health in an era of genome-based and " personalized" medicine. A number of key themes emerged, suggesting a need to reconfigure both the focus for existing genomic research and the stage at which funding is targeted, so that priority is given to areas of greatest potential health impact and that translation from basic science to implementation is given greater emphasis. To support these developments, there should be an immediate, sustained and systematic effort to provide an evidence base. These deliberations formed the basis for six key recommendations, which could guide the practice of public health in an era of genomics and personalized medicine.

KW - ethics

KW - genomics

KW - global health

KW - public health

KW - research priorities

KW - translation

UR - http://www.scopus.com/inward/record.url?scp=78650646491&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=78650646491&partnerID=8YFLogxK

U2 - 10.1097/GIM.0b013e3182011222

DO - 10.1097/GIM.0b013e3182011222

M3 - Article

VL - 12

SP - 785

EP - 791

JO - Genetics in Medicine

JF - Genetics in Medicine

SN - 1098-3600

IS - 12

ER -