Extension of short cycles in postpartum beef cows by intrauterine treatment with catecholestradiol

K. P. Nephew, S. P. Ford, M. L. Day, W. F. Pope

Research output: Contribution to journalArticle

8 Scopus citations

Abstract

Eight multiparous beef cows were used to examine the effects of intrauterine infusion of catecholestradiol (4-hydroxylated estradiol) on development and function of the first corpus luteum after parturition. Calves were weaned on day 1 (day 0 = parturition) to initiate formation of a corpus luteum (CL) by approximately day 10 or 11. Before CL formation, on days 5 to 9, cows received twice daily infusions of catecholestradiol (4 μg; n = 4) or vehicle (n = 4) into the uterine horn opposite the previous pregnancy. Plasma progesterone during the first estrous cycle was elevated longer (P<.001) and reached a higher (P<.001) concentration in cows treated with catecholestradiol. The decline in progesterone was associated with an increase in plasma 13,14-dihydro, 15-keto-prostaglandin F2α (PGFM) in all cows infused with catecholestradiol. In contrast, a rise in PGFM at the end of the first short cycle was detected in only one of four cows treated with vehicle. Furthermore, PGFM concentrations were linearly related (R2 = .870; P<.001) to concentrations of progesterone. Estradiol-17β concentrations were not different during the infusion period, but after formation of the first CL, estradiol remained elevated (P<.01) in cows that received vehicle. Results of this experiment suggest that exposure of postpartum beef cows to catecholestradiol extended luteal function in association with enhanced PGFM release.

Original languageEnglish (US)
Pages (from-to)363-370
Number of pages8
JournalDomestic Animal Endocrinology
Volume6
Issue number4
DOIs
StatePublished - Oct 1989
Externally publishedYes

ASJC Scopus subject areas

  • Food Animals
  • Animal Science and Zoology
  • Endocrinology

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